Supramolecular Peptide Therapeutics:Host-Guest Interaction-Assisted Systemic Delivery of Anticancer Peptides  

作　　者：Hua Wang Ya-Qiong Yan Yu Yi Zi-Yu Wei Hao Chen Jiang-Fei Xu Hao Wang Yuliang Zhao Xi Zhang 

机构地区：[1]Key Laboratory of Organic Optoelectronics&Molecular Engineering,Department of Chemistry,Tsinghua University,Beijing 100084 [2]CAS Center for Excellence in Nanoscience,CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,National Center for Nanoscience and Technology(NCNST),Beijing 100190

出　　处：《CCS Chemistry》2020年第6期739-748,共10页中国化学会会刊（英文）

基　　金：supported financially by the Ministry of Science and Technology of China(2018YFA0208900 and 2018YFE0205400);the National Natural Science Foundation of China(21821001,21805058,and 51890892).

摘　　要：The poor stability of therapeutic peptides in physiological environments hampers their therapeutic efficacy.In this work,a strategy of supramolecular peptide therapeutics(SPT)was proposed for the improvement of the stability and anticancer efficacy of the peptides in vivo.N-Terminal phenylalanine-containing cytotoxic peptides were carried in the cucurbit[7]uril-containing polymer through host–guest interactions between the phenylalanine and cucurbit[7]uril,generating the supramolecular peptide complex with high peptide encapsulation efficiency(>97%).The formation of the supramolecular peptide complex reserved the biological activities of the peptide,presenting prolonged blood circulation and improved anticancer efficacy.This SPT strategy might provide a cucurbituril-and phenylalanine-functionalized approach for the design and the development of peptide-based pharmaceuticals.

关 键 词：supramolecular chemistry uril cancer therapy anticancer peptide drug delivery 

分 类 号：O62[理学—有机化学]