SIRT1在变应性鼻炎中的作用及其研究进展  

Role of SIRT1 in allergic rhinitis and its research progress

作　　者：张静月 姜雪莲 张小兵[1,2] ZHANG Jingyue;JIANG Xuelian;ZHANG Xiaobing(the First Clinical Medical College,Lanzhou University,Lanzhou 730000,China;Department of Otorhinolaryngology Head and Neck Surgery,the First Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第一临床医学院,甘肃兰州730000 [2]兰州大学第一医院耳鼻喉头颈外科,甘肃兰州730000

出　　处：《中国耳鼻咽喉颅底外科杂志》2022年第6期123-128,共6页Chinese Journal of Otorhinolaryngology-skull Base Surgery

摘　　要：变应性鼻炎是IgE介导的鼻黏膜的非感染性炎性疾病,Th1/Th2/Th17/Treg细胞的失衡是变应性鼻炎的重要免疫学特征。沉默信息调节因子2相关酶1(SIRT1)作为III类组蛋白去乙酰化酶,在DNA修复和凋亡、肌肉和脂肪分化、神经元增殖分化、代谢、炎症反应、氧化应激中发挥重要作用。目前关于SIRT1在变应性疾病中的研究主要集中在类风湿性关节炎、系统性红斑狼疮及哮喘中,对于其在变应性鼻炎中的研究较少,本文就近年来SIRT1在变应性鼻炎中的相关研究进展作一综述。Allergic rhinitis(AR)is a noninfectious inflammatory disease of the nasal mucosa mediated by IgE.The imbalance of Th1/Th2/Th17/Treg cells is an important immunological feature of AR.The silent information regulator 2 homolog 1(SIRT1)as a Class III family of histone deacetylase enzymes,plays a significant role in DNA repair and apoptosis,muscle and adipose differentiation,neuron proliferation and differentiation,metabolism,inflammatory response and oxidative stress.The recent researches on SIRT1 in allergic diseases mainly focus on rheumatoid arthritis,systemic lupus erythematosus and asthma.There are few studies on SIRT1 in AR.This article summarized the relevant researches on the role of SIRT1 in AR.

关 键 词：变应性鼻炎 沉默信息调节因子2相关酶1 信号通路 免疫调节 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]