升降汤合半夏厚朴汤加减治疗肝郁脾虚型桥本甲状腺炎亚临床甲减的临床效果  

Clinical effect of Shengjiang Decoction combined with Banxia Houpu Decoction in the treatment of subclinical hypothyroidism of Hashimoto thyroiditis with liver depression and spleen deficiency

作　　者：张宸[1] 李景[1] 尚菊菊[1] ZHANG Chen;LI Jing;SHANG Juju(Department of Endocrinology,Beijing Hospital of Chinese Medicine,Capital Medical University,Beijing100010,China)

机构地区：[1]首都医科大学附属北京中医医院内分泌科,北京100010

出　　处：《中国医药导报》2022年第33期71-74,共4页China Medical Herald

基　　金：国家中医药管理局中医药询证能力建设项目(2019XZZX-XXG001);北京中医药大学孙思邈研究院中医药科研项目(SSMYJY-2-2021-14)。

摘　　要：目的 探讨升降汤合半夏厚朴汤加减治疗肝郁脾虚型桥本甲状腺炎亚临床甲减患者的临床效果。方法 选择2022年2月至5月首都医科大学附属北京中医医院内分泌门诊就诊的64例肝郁脾虚型桥本甲状腺炎亚临床甲减患者为研究对象,按照随机数字表法分为治疗组和对照组,每组32例。对照组给予左甲状腺素钠片,治疗组给予升降汤合半夏厚朴汤加减治疗,疗程为4周。比较两组临床疗效,比较两组治疗前后临床症状积分、血清促甲状腺激素(TSH)、甲状腺球蛋白抗体(TGAb)和甲状腺过氧化物酶抗体(TPOAb)水平。结果 治疗组临床疗效优于对照组,差异有统计学意义(P <0.05)。治疗后,治疗组乏力、失眠、排便异常、情绪烦躁或低落评分较治疗前降低,且治疗组低于对照组,差异有统计学意义(P <0.05)。治疗后,两组TSH水平较治疗前降低,差异有统计学意义(P <0.05);治疗组TPOAb和TGAb水平较治疗前降低,且治疗组低于对照组,差异有统计学意义(P <0.05)。结论 升降汤合半夏厚朴汤加减治疗可有效改善肝郁脾虚型桥本甲状腺炎亚临床甲减的临床症状、TSH及TPOAb和TGAb水平,改善甲状腺功能。Objective To investigate the clinical effect of Shengjiang Decoction combined with Banxia Houpu Decoction in the treatment of subclinical hypothyroidism of Hashimoto thyroiditis with liver depression and spleen deficiency. Methods From February to May 2022, 64 patients with subclinical hypothyroidism of Hashimoto thyroiditis with liver stagnation and spleen deficiency who visited Department of Endocrinology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University were selected as research objects. They were divided into treatment group and control group according to the random number table method, with 32 cases in each group. The control group was given Levothyroxine Sodium Tablets,and the treatment group was given Shengjiang Decoction combined with Banxia Houpu Decoction, the duration of treatment was four weeks. The clinical symptoms of the two groups were compared, the clinical symptom score, serum thyroid thyroid-stimulating hormone(TSH), thyroglobulin antibody(TGAb), and thyroid peroxidase antibody(TPOAb) before and after treatment were compared between two groups. Results The clinical efficacy of treatment group was better than that of control group, and the difference was statistically significant(P < 0.05). After treatment, the scores of fatigue, insomnia,abnormal defecation, and emotional irritability or depression in treatment group were lower than those before treatment, and the scores in treatment group were lower than those in control group, and the differences were statistically significant(P < 0.05). After treatment, the levels of TSH in two groups were lower than those before treatment, and the differences were statistically significant(P < 0.05);the levels of TPOAb and TGAb in treatment group were lower than those before treatment, and the levels of TPOAb and TGAb in treatment group were lower than those in the control group, and the differences were statistically significant(P < 0.05). Conclusion The treatment of Shengjiang Decoction combined with Banxia Hopu Decoction can e

关 键 词：桥本甲状腺炎 亚临床甲减 肝郁脾虚证 升降汤 半夏厚朴汤 

分 类 号：R581[医药卫生—内分泌]