献血者性别和年龄因素对悬浮红细胞储存期末溶血率的影响  

Influence of Blood Donors'sex and Age on Hemolysis Rate of Red Cells in Additive Solution during the Late Storage Period

作　　者：何智纯 徐蓓[1] 邱颖婕[1] 杨剑豪[1] 林俊杰[1] HE Zhi-chun;XU Bei;QIU Ying-jie(Shanghai Blood Center,Shanghai 200051)

机构地区：[1]上海市血液中心,上海200051

出　　处：《临床输血与检验》2022年第6期763-766,共4页Journal of Clinical Transfusion and Laboratory Medicine

摘　　要：目的对不同性别、献血年龄捐献的红悬液储存期末溶血率数据进行调查,为献血服务和血液质量控制相关研究提供切实数据。方法在2012年6月~2021年6月质控抽检400袋规格1单位的悬浮红细胞,于第35天无菌取样检测储存期末溶血率,按照献血者性别和献血年龄分组统计溶血率数据。结果纳入本次研究的400例储存35 d红悬液的溶血率数据,储存期末溶血率均数为0.20%,其中男性组高于女性组,18~30岁组溶血率分别低于31~40岁组与≥41岁组,组间差异有统计学意义。Logistic回归方程显示:相对女性组,男性组增加溶血率发生的风险;31~40岁组和≥41岁组较18~30岁组增加溶血率发生的风险,差异有统计学意义。结论对近10年的红悬液质量指标检测结果进行分析,数据表明献血者性别与年龄是影响溶血率的因素之一,为临床提供准确详实的质量指标参考范围。Objective To investigate the hemolysis rate of red cell suspensions during the late storage period from donors with different genders and ages,and thus provide data beneficial to scientific research on blood service and blood quality control.Methods From June 2012 to June 2021,400 bags of 1 unit suspended red blood cells were randomly sampled,and the hemolysis rate was measured by aseptic sampling on day 35 during the late storage period.The data of hemolysis rate were grouped according to the sex and age of blood donors.Results The mean hemolysis rate during the late storage period was 0.20%,among which the hemolysis rate of the male group was higher than that of the female group,and the hemolysis rate of the 18-30 year old group was lower than that of the 31~40 year old group and that of the≥41 years old group,respectively,with significant differences between the groups.Logistic regression equation showed that compared with the female group,the male group had an increased risk of hemolysis;and the 30~40 years old group and≥41 years old group reported a higher risk of hemolysis than the 18~30 years old group,the difference being statistically significant.Conclusion Our findings suggest that the sex and age of blood donors are among the important factors affecting hemolysis rate,which could provide an accurate and detailed reference range for clinical quality control.

关 键 词：悬浮红细胞 储存期末溶血率 性别 年龄 

分 类 号：R457.12[医药卫生—治疗学] R446.11[医药卫生—临床医学]