Self-Assembly of Constrained Cyclic Peptides Controlled by Ring Size  

作　　者：Kuan Hu Wei Xiong Chengjie Sun Chan Wang Jingxu Li Feng Yin Yixiang Jiang Ming-Rong Zhang Zhou Li Xinwei Wang Zigang Li 

机构地区：[1]State Key Laboratory of Chemical Oncogenomics,The School of Chemical Biology and Biotechnology,Peking University,Shenzhen Graduate School,Shenzhen 518055(China) [2]School of Advanced Materials,Peking University,Shenzhen Graduate School,Shenzhen 518055(China) [3]Beijing Institute of Nanoenergy and Nanosystems,Chinese Academy of Sciences,Beijing 100083(China) [4]Department of Advanced Nuclear Medicine Sciences,The National Institute of Radiological Sciences,The National Institutes for Quantum and Radiological Science and Technology,Chiba,263-8555(Japan) [5]Pingshan Translational Medicine Center,Shenzhen Bay Laboratory,Shenzhen 518055(China)

出　　处：《CCS Chemistry》2020年第1期42-51,共10页中国化学会会刊（英文）

基　　金：We acknowledge financial support from the Natural Science Foundation of China(grant nos.21778009,21801019,21977010,81701818,and 51803006);the Shenzhen Science and Technology Innovation Committee(nos.JCYJ20170817172023838 and JCYJ20180507181527112).

摘　　要：The de novo design of new peptide assemblies that expands the repertoire of biomaterial nanostructures has been of a tremendous challenge.Hence,it is evident that a successful research achievement in this area would increase the understanding of molecular interactions in supramolecules and create novel scaffolds exploitable in biotechnology and synthetic biology.The manipulation of cyclic peptide self-assembly is particularly intriguing for this purpose.Herein,we report that a novel type of cyclic peptides,referred to as chiral tether constrained cyclic peptides(CCP),shows promising self-assembly properties.CCPs are the first example of a controllable assembly of all-L-α-cyclic peptides with different ring sizes.A noteworthy feature of the CCP system is good tolerance of different secondary structures,ring size,and peptide sequence.Based on this system,a variety of nanostructures could be constructed,which display different physical properties,rendering it an excellent platform for molecular interaction studies.Further,demonstrate potential applications of these peptide assemblies in bioimaging and energy storage.

关 键 词：cyclic peptide SELF-ASSEMBLY chiral center ring size NANOSTRUCTURE SUPRAMOLECULES SUPERCAPACITOR 

分 类 号：O62[理学—有机化学]