金属离子调控骨免疫的研究进展  

Research progress on the osteoimmunomodulation by metal ions

作　　者：陈定 黎富尧 江千舟[1] 郭吕华[1] CHEN Ding;LI Fu-yao;JIANG Qian-zhou;GUO Lü-hua(Key Laboratory of Oral Medicine,Guangzhou Institute of Oral Disease,Affiliated Stomatological Hospital of Guangzhou Medical University,Guangzhou 510013,China)

机构地区：[1]广州医科大学附属口腔医院广州口腔病研究所,口腔医学重点实验室,广州510013

出　　处：《现代免疫学》2022年第6期547-550,共4页Current Immunology

基　　金：广东省科技计划项目(2017A050501041;2018B050502012)。

摘　　要：金属离子通过参与细胞内外信号的转导以调节体内细胞反应。金属离子是骨组织中重要的免疫调节因子。在局部骨微环境中,金属离子能诱导巨噬细胞向不同表型极化,并调控细胞分泌不同类型的细胞因子。巨噬细胞介导的骨免疫是以调控免疫细胞为中心,旨在构建适宜的免疫微环境以加快骨组织的修复和再生。文章基于金属离子对骨免疫调控的作用作一综述。Metal ions regulate cellular responses in vivo by participating in the transduction of signals inside and outside the cell. In the local bone microenvironment, metal ions are important immunomodulators. They not only induce macrophages to polarize to different phenotypes but also regulate the secretion of various cytokines. Macrophage-mediated osteoimmunomodulation revolves around the regulation of immune cells to maintain an optimal immune microenvironment and accelerate the repair and regeneration of bone tissue. This review discusses the regulation of metal ions on osteoimmunomodulation.

关 键 词：金属离子 骨免疫 巨噬细胞 

分 类 号：R392.12[医药卫生—免疫学]