国际单侧原发性醛固酮增多症病理诊断共识解读  

Interpretation on the international consensus of the pathological diagnosis of unilateral primary aldosteronism

作　　者：杨溢[1] 朱莎莎 李佳渝 宋颖[1] 杨淑敏[1] 程伟[2] 李启富[1] 重庆原醛症研究团队(CONPASS) Yang Yi;Zhu Shasha;Li Jiayu;Song Ying;Yang Shumin;Cheng Wei;Li Qifu;Chongqing Primary Aldosteronism Research Team(CONPASS)(Department of Endocrinology,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China;The Center for Clinical Molecular Medical detection,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China;Lipid and glucose metabolism laboratory,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China;不详)

机构地区：[1]重庆医科大学附属第一医院内分泌科,400016 [2]重庆医科大学附属第一医院临床分子医学检测中心,400016 [3]重庆医科大学附属第一医院脂糖代谢实验室,400016 [4]不详

出　　处：《中华内分泌代谢杂志》2022年第11期937-942,共6页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金(U21A20355、82100833);国家重点研发计划"常见多发病防治研究"重点专项(2021YFC2501600、2021YFC2501603);重庆市自然科学基金博士后科学基金(cstc2021jcyj-bshX0207)。

摘　　要：单侧原发性醛固酮增多症(原醛症)是原醛症的常见类型,可通过患侧肾上腺切除手术进行治疗。术后病理评估是单侧原醛症诊断的重要环节,并有助于指导其后续治疗及随访。组织形态学评估是单侧原醛症病理诊断的基础,而近年来兴起的醛固酮合酶免疫组化染色则极大地提升了单侧原醛症的病理诊断水平。然而,目前单侧原醛症的病理诊断也存在着命名体系和诊断标准不统一等不足。因此,以Tracy Ann Williams为首的多中心专家团队制定了《国际单侧原醛症病理诊断共识》,并于2021年发表于J Clin Endocrinol Metab杂志。本文将对该共识所涉及的要点进行解读,以期帮助临床科研工作者更全面地理解此共识,为单侧原醛症的临床诊疗提供参考。Unilateral primary aldosteronism(UPA)is a common form of PA that is surgically curable by adrenalectomy of the overactive gland.Pathological evaluation of resected adrenals is crucial in the diagnosis of UPA,and its subsequent treatment and follow-up as well.Histomorphological evaluation is the basis for the pathological diagnosis of UPA,and the wide use of aldosterone synthase immunohistochemical staining in recent years has greatly improved the pathological diagnosis of UPA.However,there is a lack of standardized nomenclature and diagnostic criteria.Therefore,consensus on the histopathologic diagnosis of UPA were developed by an international group of pathologists led by Tracy Ann Williams,and published in J Clin Endocrinol Metab,2021.This article will elaborates on the key points in the consensus to advance the understanding and overall improve clinical mangement of UPA.

关 键 词：单侧原发性醛固酮增多症 病理诊断 共识 醛固酮合酶 免疫组织化学 

分 类 号：R586.24[医药卫生—内分泌]