黄芪建中汤联合艾灸治疗脾虚型消化性溃疡的疗效及对患者血清VEGF、bFGF水平的影响探讨  

Efficacy of Huangqi Jianzhong Decoction combined with moxibustion on spleen deficiency type of peptic ulcer and its influence on serum levels of VEGF and bFGF

作　　者：丁淑婷 戴孟 叶方益 金瑞环 DING Shu-ting;DAI Meng;YE Fang-yi(Department of Traditional Chinese Medicine,Ruian Hospital of Traditional Chinese Medicine,Ruian 325200,China)

机构地区：[1]瑞安市中医院中医内科,325200

出　　处：《中国实用医药》2022年第26期150-153,共4页China Practical Medicine

基　　金：温州市中医药科学研究项目资助(项目编号:2018ZB022)。

摘　　要：目的探讨黄芪建中汤联合艾灸治疗脾虚型消化性溃疡的疗效及对患者血清血管内皮生成因子(VEGF)、碱性成纤维细胞生长因子(bFGF)的影响。方法60例脾虚型消化性溃疡患者,采用随机数字表法分为对照组和观察组,各30例。对照组给予常规抑酸、保护胃黏膜及根除幽门螺杆菌(Hp)治疗,观察组在对照组基础上加用黄芪建中汤联合艾灸治疗。比较两组患者临床疗效,治疗前后中医症状积分及血清VEGF、bFGF水平。结果观察组患者治疗总有效率为93.3%,高于对照组的66.7%,差异有统计学意义(P<0.05)。治疗前,两组患者中医症状积分比较差异无统计学意义(P>0.05);治疗后,两组患者中医症状积分均低于治疗前,且观察组患者中医症状积分(4.4±3.2)分低于对照组的(8.3±4.5)分,差异有统计学意义(P<0.05)。治疗前,两组患者血清VEGF、bFGF水平比较差异无统计学意义(P>0.05);治疗后,两组患者血清VEGF、bFGF水平均高于治疗前,且观察组患者血清VEGF(147.4±34.3)pg/ml、bFGF(188.2±43.6)pg/ml高于对照组的(115.5±29.2)、(132.3±39.2)pg/ml,差异有统计学意义(P<0.05)。结论黄芪建中汤联合艾灸治疗脾虚型消化性溃疡疗效显著,可明显提高患者血清VEGF、bFGF水平,改善患者症状,值得推广。Objective To discuss the efficacy of Huangqi Jianzhong Decoction combined with moxibustion on spleen deficiency type of peptic ulcer and its influence on serum levels of vascular endothelial growth factor(VEGF)and basic fibroblast growth factor(bFGF).Methods A total of 60 patients with spleendeficiency type of peptic ulcer were divided into a control group and an observation group according to the random numerical table,with 30 cases in each group.The control group was treated with conventional therapy of acid suppression,gastric mucosa protection and eradication of Helicobacter pylori(Hp),while the observation group was treated with Huangqi Jianzhong Decoction combined with moxibustion on the basis of the control group.The clinical efficacy,traditional Chinese medicine symptom scores and serum VEGF and bFGF levels before and after treatment were compared between the two groups.Results The total effective rate of treatment for patients in the observation group was 93.3%,which was higher than 66.7% in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in traditional Chinese medicine symptom scores between the two groups(P>0.05).After treatment,the traditional Chinese medicine symptom scores in both groups were lower than those before treatment in this group,and the traditional Chinese medicine symptom scores(4.4±3.2)points in the observation group were lower than(8.3±4.5)points in the control group,and the difference was statistically significant(P<0.05).Before treatment,the differences in serum VEGF and bFGF levels between the two groups were not statistically significant(P>0.05).After treatment,the serum VEGF and bFGF levels in both groups were higher than those before treatment in this group;the serum VEGF(147.4±34.3)pg/ml and bFGF(188.2±43.6)pg/ml in the observation group were higher than(115.5±29.2)and(132.3±39.2)pg/ml in the control group;and the differences were all statistically significant(P<0.05).Conclusion H

关 键 词：脾虚型消化性溃疡 黄芪建中汤 艾灸 血管内皮生成因子 碱性成纤维细胞生长因子 

分 类 号：R259[医药卫生—中西医结合]