高效液相色谱法测定防晒类化妆品中邻甲氨基苯甲酸甲酯  

Determination of methyl methylanthranilate by high performance liquid chromatography in sunscreen cosmetics

作　　者：吴志珊 姜成君 殷帅 黄海萍 章为 Zhishan Wu;Chengjun Jiang;Shuai Yin;Haiping Huang;Wei Zhang(Hunan Institute for Drug Control,Changsha,Hunan 410001,China)

机构地区：[1]湖南省药品检验检测研究院,湖南长沙410001

出　　处：《日用化学工业（中英文）》2022年第12期1348-1352,共5页China Surfactant Detergent & Cosmetics

摘　　要：建立了一种高效液相色谱法测定防晒类化妆品中邻甲氨基苯甲酸甲酯含量的方法。样品经提取、超声、过滤后,采用Welch Xtimate^(®)C_(18)色谱柱分离,高效液相色谱-二极管阵列检测器进行定性、定量分析。在本实验条件下,邻甲氨基苯甲酸甲酯能与防晒类化妆品中常见的22种防晒剂进行分离,其质量浓度与峰面积之间呈良好的线性关系(r=0.9996),检出限为0.009%,定量限为0.029%,在高、中、低三种质量浓度的添加回收率实验中,回收率在99.33%~111.5%之间,RSD在0.3%~3.0%之间。该方法专属性强、准确度高,适用于防晒类化妆中邻甲氨基苯甲酸甲酯含量的测定。A high performance liquid chromatography(HPLC)method was established for the determination of methyl methylanthranilate in sunscreen cosmetics.After extraction,sonication and filtration,the samples were separated by Welch Xtimate^(®)C_(18)chromatographic column,and qualitative and quantitative analysis were carried out by HPLC with PDA detector.Under the experimental conditions,there is a good linear relationship between peak areas and methyl methylanthranilate concentrations with the r value is 0.9996.The detection limit is 0.009%,and the limit of quantification is 0.029%.The average recoveries are in the range of 99.33%-111.5%and the relative standard deviations are in the range of 0.3%-3.0%.This accurate and exclusive method is suitable for the qualitative and quantitative analysis of methyl methylanthranilate in sunscreen cosmetics.

关 键 词：邻甲氨基苯甲酸甲酯 防晒类化妆品 高效液相色谱法 

分 类 号：TQ658[化学工程—精细化工]