类菌胞素氨基酸的性质及其在化妆品领域中应用的研究进展  

Research progress in cosmetics applications and properties of mycosporine-like amino acids

作　　者：范高宁 Gaoning Fan(Taizhou Medical Hi-Tech Zone New Drug Application Center,Taizhou,Jiangsu 225300,China)

机构地区：[1]泰州医药高新技术产业园区新药申报服务中心,江苏泰州225300

出　　处：《日用化学工业（中英文）》2022年第12期1366-1372,共7页China Surfactant Detergent & Cosmetics

摘　　要：类菌胞素氨基酸(mycosporine-like amino acids,MAAs)是一类水生生物次级代谢产物,广泛存在于多种水生生物中。它们是由氨基环己烯酮或氨基环己亚胺环组成。据研究,类菌胞素氨基酸具有罕见的紫外光防护作用,本文主要介绍类菌胞素氨基酸的来源、结构、理化性质、生物合成途径、生物活性及其在化妆品领域应用的研究进展。Mycosporine-like amino acids(MAAs)are a class of secondary metabolites of aquatic organisms,which are widely distributed in algae,phytoplankton,cyanobacteria,microorganisms and marine animals.MAAs are low-molecular-weight(generally<400 Da),colorless and water-soluble compounds.They are highly stable molecules under environmental conditions.They are composed of either an aminocyclohexenone or an aminocyclohexenimine ring.Multiple lines of evidence have supported that MAAs are derived from intermediates of the shikimate pathway and the pentose phosphate pathway.MAAs maximally absorb in the wavelength region of 268-362 nm and also exhibit high molar absorptivities(12400-58800 L/(mol·cm)).Therefore,due to these characteristics,they are the strongest UVA-absorbing compounds in nature.MAAs have potential for development as natural biocompatible sunscreens that protect against a diverse range of solar UVR which has induced adverse effects on human health.In addition,MAAs have additional protective roles such as antioxidant function and anti-aging.Herein,the research on the distribution,chemical structure,physico-chemical characteristics,biosynthesis,bioactivities of MAAs and their application in cosmetics are mainly introduced.

关 键 词：类菌胞素氨基酸 紫外线防护 来源 生物合成途径 生物活性 

分 类 号：TQ658[化学工程—精细化工]