黑磷纳米片协同药物递送的作用效应研究进展  

Research Progress of Synergistic Effect of Black Phosphorus Nanosheets on Drug Delivery

作　　者：詹燕蕾 孙平[2] 徐希明[1] 李凤前[2] ZHAN Yan-lei;SUN Ping;XU Xi-ming;LI Feng-qian(School of Pharmacy,Jiangsu University,Zhenjiang 212013,China;Shanghai Eighth People′s Hospital,Shanghai 200235,China)

机构地区：[1]江苏大学药学院,江苏镇江212013 [2]上海市第八人民医院,上海200235

出　　处：《中国药学杂志》2022年第20期1697-1702,共6页Chinese Pharmaceutical Journal

摘　　要：黑磷纳米片(black phosphorus nanosheets,BPNs)作为新型可生物降解材料,具有良好的生物相容性和独特的光热/光动力效应。近年来的研究表明,负载BPNs的药物递送系统可有效通过光热效应和光动力效应,发挥高效载药、赋能热响应与光动力氧化应激作用,应用于抗肿瘤、抗菌和促进骨再生等领域的研究。BPNs在药物递送系统中对于药物释放调控、光热/光动力效应协同作用和提高疗效方面具有显著优势和应用潜力。本文对BPNs的理化特性、生物特性及其协同药物递送的作用效应研究进展进行综述,为其进一步的研究提供参考。Black phosphorus nanosheets(BPNs),as a new biodegradable material,have good biocompatibility and unique photo-thermal/photodynamic effect.Recent studies have shown that the drug delivery system loaded with BPNs can effectively exert the effects of high-efficiency drug loading,enabling thermal response and photodynamic oxidative stress through photo-thermal effect and photodynamic effect,and could be applicated to the research fields of anti-tumor,antibacterial and promoting bone regeneration.BPNs have significant advantages and application potential in drug delivery system for controlled drug release regulation,photo-thermal/photodynamic effect synergy and enhanced therapeutic efficacy.This paper reviews the research progress of physical and chemical properties,biological properties and synergistic drug delivery of BPNs,so as to provide reference for its further research.

关 键 词：黑磷纳米片 协同 药物递送系统 作用效应 

分 类 号：R94[医药卫生—药剂学]