中西医结合治疗儿童特发性矮小Meta分析  

Meta-analysis of children idiopathic short stature treated by integrated traditional Chinese and western medicine

作　　者：丛明 董丹[2] 吕珂瑶 王雪峰[2] 王广海 CONG Ming;DONG Dan;LYU Keyao;WANG Xuefeng;WNAG Guanghai(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China)

机构地区：[1]辽宁中医药大学,沈阳110847 [2]辽宁中医药大学附属医院儿科 [3]中国医科大学,沈阳110000 [4]上海交通大学医学院附属上海儿童医学中心发育行为儿科,上海200127

出　　处：《中国中西医结合儿科学》2022年第6期545-552,共8页Chinese Pediatrics of Integrated Traditional and Western Medicine

摘　　要：目的系统评价中西医结合治疗与单纯应用西医治疗儿童特发性矮小的临床对比效果,为临床治疗儿童特发性矮小提供循证医学的参考。方法研究人员独立检索中国知网(CNKI)、万方数据库(WANFANG)、维普数据库(VIP)、中国生物医学数据库(CBM)、PubMed,检索的时间范围为各文献数据库从建库至2022年5月31日,将最终符合纳入标准的文献应用Cochrane网站提供的RevMan 5.4.1软件进行数据统计与分析。结果纳入此次研究的共有18篇随机对照临床试验,样本量共有1572例,其中观察组782例,对照组790例。Meta分析的森林图显示,应用中医药综合治疗与西医联合治疗的观察组在总有效率、患儿身高体质量增长情况、胰岛素样生长因子-1(IGF-1)及胰岛素样生长因子结合蛋白-3(IGFBP-3)提升水平都明显优于单纯应用西医治疗的对照组。结论中医药综合治疗配合西医疗法比单纯应用西医疗法在治疗儿童特发性矮小上发挥了更显著的效果,因此,在临床实际治疗过程中,可在准确辨证的前提下加以配合使用中医药综合疗法来提高儿童特发性矮小的临床治疗效果。Objective To systematically evaluate the clinical effect of combining traditional Chinese with western medicine and western medicine alone in treating children’s idiopathic short stature(ISS),and to provide evidence-based medical reference for clinical treatment of children’s idiopathic short stature.Methods Researchers retrieved CNKI,WANFANG,VIP,CBM and PubMed,the retrieval time for each database was from its establishment to May 31,2022.The literature which eventually met eligibility criteria was analyzed by RevMan 5.4.1 software provided by Cochrane website.Results A total of 18 randomized controlled clinical trials were included in the study,sample size being 1572 cases,among which 782 were in experimental group and 790 cases in control group.The forest plot meta-analysis showed that the total response rate of the experimental group receiving Chinese medicine combined with western medicine was significantly higher than that of the control group treated with western medicine alone,and it was the same with the growth of height and weight of children,and the improvement of insulin-like growth factor-1(IGF-1)and insulin-like growth factor-binding protein-3(IGFBP-3).Conclusion In the treatment of children with idiopathic short stature children,the role of Chinese medicine combined with western medicine is more significant than the western medicine alone.Therefore,in the clinical treatment process,it can be used in combination with Chinese medicine on the premise of accurate syndrome differentiation to improve the treatment effect on children with ISS.

关 键 词：特发性矮小 中医药 中西医结合 META分析 

分 类 号：R339.35[医药卫生—人体生理学]