甲泼尼龙琥珀酸钠联合大环内酯类抗生素在小儿反复下呼吸道肺炎支原体感染中的应用效果  

Application Effect of Methylprednisolone Sodium Succinate Combined with Macrolide Antibiotics in Children with Recurrent Lower Respiratory Tract Mycoplasma Infection

作　　者：陈海龙 温才旺 凌曦 CHEN Hailong;WEN Caiwang;LING Xi(Shaoguan Maternal and Child Health Hospital,Guangdong Province,Shaoguan 512026,China;不详)

机构地区：[1]广东省韶关市妇幼保健院,广东韶关512026

出　　处：《中国医学创新》2022年第36期37-41,共5页Medical Innovation of China

基　　金：广东省医学科学技术研究基金(韶卫[2011]Y12048)。

摘　　要：目的:探讨甲泼尼龙琥珀酸钠联合大环内酯类抗生素对小儿反复下呼吸道肺炎支原体感染的疗效及血清炎症反应指标的影响。方法:选取2019年6月-2021年3月韶关市妇幼保健院收治的80例反复下呼吸道肺炎支原体感染患儿,根据治疗方式的不同将其分为单一用药组和联合用药组,每组40例。单一用药组采用阿奇霉素序贯疗法,联合用药组在此基础上加用甲泼尼龙琥珀酸钠。比较两组患儿临床疗效、治疗时间、治疗前后血清炎症因子水平、随访1年再入院率及用药安全性。结果:单一用药组患儿的临床总有效率为70.00%,低于联合用药组患儿的90.00%(P<0.05)。单一用药组患儿的退热时间、咳嗽和肺部啰音消失时间和住院时间均比联合用药组长(P<0.05)。治疗后,两组C反应蛋白(CRP)、血清淀粉样蛋白A(SAA)和白介素-6(IL-6)均低于治疗前,联合用药组均低于单一用药组(P<0.05)。随访1年后联合用药组患儿再入院发生率低于单一用药组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:甲泼尼龙琥珀酸钠联合大环内酯类抗生素治疗小儿反复下呼吸道肺炎支原体感染可有效减轻血清炎症因子反应,缩短治疗时间,提高临床疗效,降低再入院率。Objective:To investigate the efficacy of Methylprednisolone Sodium Succinate combined with macrolide antibiotics in children with recurrent lower respiratory tract mycoplasma infection and its influence on serum inflammatory response indicators.Method:A total of 80 children with recurrent lower respiratory tract mycoplasma infection admitted to Shaoguan Maternal and Child Health Hospital from June 2019 to March 2021were selected,and they were divided into monotherapy group and combination group according to different treatment methods,with 40 cases in each group.The monotherapy group received Azithromycin sequential treatment,and the combination group received Methylprednisolone Sodium Succinate on this basis.Clinical efficacy,treatment duration,serum inflammatory factor levels before and after treatment,1-year follow-up readmission rate and medication safety were compared between the two groups.Result:The total efficiency of the monotherapy group was 70.00%,which was lower than 90.00% of the combination group(P<0.05).The antipyretic time,the absence of cough and pulmonary rales,and the length of hospital stay of the monotherapy group were longer than those of the combination group(P<0.05).After treatment,C reactive protein(CRP),serum amyloid A protein(SAA) and interleukin-6(IL-6) of both groups were lower than those before treatment,those of the combination group were lower than those of the monotherapy group(P<0.05).After 1 year of follow-up,the incidence of readmission of the combination group was lower than that of the monotherapy group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Methylprednisolone Sodium Succinate combined with macrolide antibiotics in the treatment of recurrent lower respiratory tract mycoplasma infection in children can effectively reduce the response of serum inflammatory factors,shorten the treatment time,improve the clinical efficacy,and reduce the readhospital rate.

关 键 词：甲泼尼龙琥珀酸钠 阿奇霉素 反复下呼吸道感染 炎症因子 

分 类 号：R725.6[医药卫生—儿科]