富血小板血浆治疗钙化性冈上肌腱炎的效果观察  

Observation on the Effect of Platelet-rich Plasma in the Treatment of Calcified Supraspinatus Tendinitis

作　　者：朱岩[1] ZHU Yan(Jiamusi Central Hospital,Heilongjiang Province,Jiamusi 154002,China)

机构地区：[1]黑龙江省佳木斯市中心医院,黑龙江佳木斯154002

出　　处：《中国医学创新》2022年第34期147-150,共4页Medical Innovation of China

摘　　要：目的:观察富血小板血浆(PRP)治疗钙化性冈上肌腱炎(CST)的效果。方法:选取2020年1月-2021年9月佳木斯市中心医院疼痛科收治的82例CST患者,采用随机数字表法分为两组,每组41例。对照组给予体外冲击波(ESW)治疗,观察组在对照组治疗基础上加用PRP治疗。比较两组肩关节疼痛[视觉模拟评分法(VAS)]和肩关节功能[Constant-Murley肩关节功能评分(CMS)和美国肩肘外科协会评分(ASES)]、肩关节钙化灶大小、疗效、炎症因子[白细胞介素-1α(IL-1α)、白细胞介素-33(IL-33)和白细胞介素-1β(IL-1β)]和不良反应。结果:治疗后,两组VAS评分均较治疗前降低,CMS和ASES评分均较治疗前升高,且观察组VAS评分低于对照组,而CMS和ASES评分均高于对照组(P<0.05)。治疗后,两组钙化灶面积均较治疗前减小,且观察组小于对照组(P<0.05)。观察组总有效率(92.68%)高于对照组(73.17%)(P<0.05)。治疗后,两组血清IL-1α、IL-33和IL-1β水平均较治疗前降低,且观察组均低于对照组(P<0.05)。观察组(14.63%)与对照组(7.32%)不良反应发生率比较,差异无统计学意义(P>0.05)。结论:PRP可明显减轻CST患者的肩关节疼痛,改善肩关节功能,促进钙化灶吸收,其机制可能与下调血清IL-1α、IL-33和IL-1β等炎症因子水平,减轻炎症反应有关。Objective:To observe the effect of platelet-rich plasma(PRP)in the treatment of calcified supraspinatus tendinitis(CST).Method:A total of 82 patients with CST who were admitted to the Pain Department of Jiamusi Central Hospital from January 2020 to September 2021 were selected and divided into two groups by random number table method,with 41 cases in each group.The control group was given extracorporeal shock wave(ESW)treatment,and the observation group was additionally given PRP treatment on the basis of the treatment of the control group.Shoulder joint pain[visual analogue scale(VAS)]and shoulder joint function[Constant-Murley shoulder function score(CMS)and American shoulder and elbow surgeons(ASES)],shoulder calcification focus size,efficacy,inflammatory factors[interleukin-1α(IL-1α),interleukin-33(IL-33)and interleukin-1β(IL-1β)]and adverse effects were compared between the two groups.Result:After treatment,the VAS scores of the two groups were decreased,the CMS and ASES scores were increased compared with before treatment,and the VAS scores of the observation group was lower than that of the control group,while the CMS and ASES scores were higher than those of the control group(P<0.05).After treatment,the area of calcification focus in both groups were decreased compared with before treatment,and the observation group was smaller than that of the control group(P<0.05).The total effective rate in the observation group(92.68%)was higher than that in the control group(73.17%)(P<0.05).After treatment,the serum levels of IL-1α,IL-33 and IL-1βin both groups were decreased compared with before treatment,and the observation group were lower than those of the control group(P<0.05).There was no significant difference in incidence of adverse reactions between the observation group(14.63%)and the control group(7.32%)(P>0.05).Conclusion:PRP can significantly reduce shoulder joint pain in CST patients,improve shoulder joint function,and promote the absorption of calcification focus.The mechanism may be related to d

关 键 词：富血小板血浆 钙化性冈上肌腱炎 肩关节功能 炎症因子 钙化灶 

分 类 号：R686.1[医药卫生—骨科学]