火针联合他克莫司软膏和地氯雷他定治疗局限性神经性皮炎患者的疗效  

Efficacy of fire needle combined with tacrolimus ointment and desloratadine in the treatment of localized neurodermatitis

作　　者：李玉蕊 陈萍 郭东方 LI Yu-rui;CHEN Ping;GUO Dong-fang

机构地区：[1]南阳张仲景医院皮肤科,473000

出　　处：《中国疗养医学》2023年第2期192-196,共5页Chinese Journal of Convalescent Medicine

摘　　要：目的探讨火针联合他克莫司软膏、地氯雷他定治疗局限性神经性皮炎(limited neurodermatitis,LND)患者的疗效,及对患者靶皮损面积、皮肤严重程度、皮肤生理功能、免疫功能、炎性因子的影响。方法收集2019年5月至2020年7月在南阳张仲景医院确诊并接受治疗的LND患者72例,根据接受的治疗方案不同,分为药物治疗组(n=36)和火针联合药物组(n=36)。药物治疗组采用他克莫司软膏涂抹患处和地氯雷他定口服治疗,火针联合药物组在药物治疗组的基础上联合火针治疗。比较两组总有效率、靶皮损面积、严重程度(EASI评分)、皮肤生理功能指标[表皮的水分流失(TEWL)、皮肤的油脂(SC)、角质层的含水量(WCSC)]、免疫功能指标[细胞间的黏附分子-1(ICAM-1)、血管细胞的黏附分子-1(VCAM-1)、免疫球蛋白E(IgE)]、炎性因子指标[白介素-4(IL-4)、干扰素-γ(IFN-γ)]和不良反应发生率。结果治疗后,火针联合药物组总有效率(94.44%)高于药物治疗组(75.00%),P<0.05;治疗后,火针联合药物组靶皮损面积、EASI评分比较均低于药物治疗组(P<0.05);治疗后,火针联合药物组WCSC、SC均高于药物治疗组,TEWL低于药物治疗组(P<0.05);治疗后,火针联合药物组ICAM-1、VCAM-1、IL-4、IgE水平均低于药物治疗组,IFN-γ水平高于药物治疗组(P<0.05);两组总不良反应发生率比较,差异无统计学意义(P>0.05)。结论火针联合他克莫司软膏、地氯雷他定治疗LND可明显提高治疗效果,减少皮疹和瘙痒范围和严重程度,改善皮肤生理功能,并提高患者的免疫功能,减轻患者的炎性状态,促进疾病的康复。Objective To investigate the efficacy of fire needle combined with Tacrolimus ointment and Desloratadine in the treatment of patients with limited neurodermatitis(LND),and the effects on target skin area,skin severity,skin physiological function,immune function and inflammatory factors.Methods A total of 72 patients with LND who were diagnosed and treated in Nanyang ZhangZhongjing Hospital from May 2019 to July 2020 were collected and divided into drug therapy group(n=36)and fire needle combined drug group(n=36)according to different treatment regimens.The drug treatment group was treated with Tacrolimus ointment and oral Desloratadine,and the fire needle combined with drug therapy group was treated with fire needle on the basis of drug therapy group.The total effective rate,target skin lesion area,severity(EASI score),skin physiological function indexes[transepidermal water loss(TEWL),stratum corneum(SC),water content of stratum corneum(WCSC)],immune function indexes[intercellular adhesion molecule-1(ICAM-1),vascular cell adhesion molecule-1(VCAM-1),immunoglobulin E(IgE),immunoglobulin E(IgE)],inflammatory factor indicators[interleukin-4(IL-4),interferon-γ(IFN-γ)]and the incidence of adverse reactions were compared between the two groups.Results After treatment,the total effective rate(94.44%)in the fire-needle combined drug group was higher than that in the drug treatment group(75.00%),P<0.05;After treatment,the target lesion area and EASI score in the combined group were lower than those in the drug treatment group(P<0.05).After treatment,WCSC and SC in the combined group were higher than those in the drug treatment group,and TEWL was lower than that in the drug treatment group(P<0.05).After treatment,the levels of ICAM-1,VCAM-1,IL-4 and Ig E in the fire-needle combined drug group were lower than those in the drug treatment group,and the levels of IFN-γwere higher than that in the drug treatment group(P<0.05).There was no significant difference in the incidence of total adverse reactions between the two gro

关 键 词：火针 他克莫司软膏 地氯雷他定 局限性神经性皮炎 

分 类 号：R758.32[医药卫生—皮肤病学与性病学]