柴胡-黄芩对急性胰腺炎大鼠的抗炎及镇痛作用研究  

Anti-inflammatory and Analgesic Effects of Bupleurum-Scutellara on Rats with Acute Pancreatitis

作　　者：陈丹丹[1] 宋亮[1] 卫培峰[1] Chen Dandan;Song Liang;Wei Peifeng(Shaanxi University of Chinese Medicine,Xianyang 712046,China)

机构地区：[1]陕西中医药大学,陕西咸阳712046

出　　处：《中国野生植物资源》2022年第12期1-4,共4页Chinese Wild Plant Resources

基　　金：陕西省科技厅项目(2019SF-294);陕西省“特支计划”区域发展人才项目(2017年)。

摘　　要：目的:探讨柴胡-黄芩是否可以减轻急性胰腺炎大鼠的炎性反应和疼痛反应。方法:选取SD大鼠,采用腹腔注射L-精氨酸复制急性胰腺炎模型,随后给予柴胡-黄芩水煎液灌胃,观察柴胡-黄芩对大鼠疼痛行为,血清IL-6、IL-1β、TNF-α、CAT、GSH-Px、MDA水平,以及NF-κB通路活性的影响。结果:柴胡-黄芩能延长急性胰腺炎大鼠疼痛行为第1次出现时间,降低血清IL-6、IL-1β、TNF-α水平,升高大鼠体内CAT、GSH-Px活力,降低MDA水平,抑制NFκB通路活化。结论:柴胡-黄芩通过抑制NFκB通路活化和提高抗氧化作用保护急性胰腺炎。Objective:To investigate whether Bupleurum-Scutellara can alleviate the inflammatory and pain responses of rats on acute pancreatitis.Methods:Acute pancreatitis was induced by intraperitoneal injection of L-arginine on SD rats,and then intragastrically administered of Bupleurum-Scutellara decoction to observe the pain behavior,IL-6,IL-1β,TNF-α,CAT,GSH-Px,MDA levels in serum and NFκB pathway activity of Bupleurum-Scutellara in rats.Conclusion:Bupleurum-Scutellara protected acute pancreatitis by inhibiting the activation of NFκB pathway and improved its antioxidant effects.

关 键 词：柴胡-黄芩 急性胰腺炎 止痛作用 抗炎作用 

分 类 号：R285.5[医药卫生—中药学]