左氧氟沙星灌注治疗慢性子宫内膜炎不孕症患者的效果及对炎症因子、妊娠结局的影响  

Effect of Levofloxacin perfusion in the treatment of patients with chronic endometritis and infertility and its influence on inflammatory factors and pregnancy outcomes

作　　者：周彩霞[1] 代会颖 郑小莉[1] ZHOU Caixia;DAI Huiying;ZHENG Xiaoli(Department of Gynecology,the First People’s Hospital of Xuzhou,Jiangsu Province,Xuzhou 221100,China)

机构地区：[1]江苏省徐州市第一人民医院妇科,江苏徐州221100

出　　处：《妇儿健康导刊》2023年第1期138-140,155,共4页JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE

摘　　要：目的探讨左氧氟沙星灌注治疗慢性子宫内膜炎不孕症患者的效果及对炎症因子、妊娠结局的影响。方法将2020年1月至2021年12月在徐州市第一人民医院妇科治疗的96例慢性子宫内膜炎不孕症患者按随机数字表法分为两组,每组各48例。对照组使用常规甲硝唑及左氧氟沙星静脉滴注治疗,观察组使用左氧氟沙星宫腔灌注治疗。比较两组临床疗效、血清炎症因子水平、妊娠结局。结果观察组治疗总有效率为93.75%,高于对照组的72.92%,差异有统计学意义(P<0.05);观察组治疗后血清白介素-1β、白介素-6、肿瘤坏死因子-α、基质金属蛋白酶-9水平低于对照组,白介素-2水平高于对照组,差异有统计学意义(P<0.05);观察组临床妊娠率高于对照组,差异有统计学意义(P<0.05);两组生化妊娠、流产率比较,差异无统计学意义(P>0.05)。结论左氧氟沙星灌注治疗慢性子宫内膜炎不孕症患者的效果显著,能有效对抗炎症,改善子宫内膜容受性,提高妊娠率。Objective To explore the effect of Levofloxacin perfusion in the treatment of patients with chronic endometritis and infertility and its influence on inflammatory factors and pregnancy outcomes.Methods A total of 96 patients with chronic endometritis and infertility treated in the Department of Gynecology of the First People’s Hospital of Xuzhou from January 2020 to December 2021 were divided into two groups according to the random number table method,with 48 patients in each group.The control group was treated with routine Metronidazole and Levofloxacin intravenous infusion,while the observation group was treated with Levofloxacin intrauterine infusion.The clinical efficacy,serum inflammatory factor levels and pregnancy outcome were compared between the two groups.Results The total effective rate of the observation group was 93.75%,which was higher than that of the control group(72.92%),and the difference was statistically significant(P<0.05).After treatment,the levels of serum interleukin-1β,interleukin-6,tumor necrosis factor-αand matrix metalloprotein-9 in the observation group were lower than those in the control group,while the level of interleukin-2 was higher than that in the control group,the differences were statistically significant(P<0.05).The clinical pregnancy rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).The biochemical pregnancy and abortion rate of the two groups were compared,the differences were not statistically significant(P>0.05).Conclusion Levofloxacin perfusion in the treatment of patients with chronic endometritis and infertility has a significant effect,can effectively fight inflammation,improve endometrium receptivity,improve pr egnancy rate.

关 键 词：慢性子宫内膜炎 左氧氟沙星 宫腔灌注 疗效 炎症因子 妊娠结局 

分 类 号：R711[医药卫生—妇产科学]