猪流行性腹泻病毒疫苗研究进展  

Research progress on porcine epidemic diarrhea virus vaccines

作　　者：景鼎鼎 朱春华[2] 肖方南 王晶晶[1] 张红 吴琳娇 陈磊清 吴允昆 JING Dingding;ZHU Chunhua;XIAO Fangnan;WANG Jingjing;ZHANG Hong;WU Linjiao;CHEN Leiqing;WU Yunkun(Collegeof Life Sciences,Fujian Normal University,Fuzhou 350108,China;Institute of Animal Husbandry and Veterinary Medicine,Fujian Academy of Agricultural Sciences,Fuzhou 350013,China)

机构地区：[1]福建师范大学生命科学学院,福建福州350108 [2]福建省农业科学院畜牧兽医研究所,福建福州350013

出　　处：《中国兽医学报》2022年第10期2117-2124,共8页Chinese Journal of Veterinary Science

摘　　要：猪流行性腹泻病毒(porcine epidemic diarrhea virus, PEDV)是引起仔猪严重肠道疾病的主要病原,对仔猪具有极高的致死率,给全球养猪行业造成难以估量的经济损失。疫苗作为疫情防控中最有效的手段,其研发工作备受关注。从传统疫苗到基于DNA重组技术诞生的基因工程疫苗如亚单位疫苗、活载体疫苗、转基因植物疫苗以及第3代疫苗,在遏制PEDV疫情蔓延方面均发挥着重要作用。近些年,PEDV疫苗研发取得显著成绩,现对PEDV各种类型疫苗取得的研究成果展开系统回顾,并探讨和展望纳米颗粒在PEDV疫苗开发中的应用前景,以期为猪场PEDV的综合预防提供参考。Porcine epidemic diarrhea virus(PEDV) is the main pathogen that causes serious enteric diseases in piglets, which has a very high mortality rate to piglets and causes immeasurable economic losses to the global pig industry.As the most effective means of epidemic prevention and control, the vaccines development has attracted much attention.From traditional vaccines to genetically engineered vaccines based on DNA recombination technology such as subunit vaccines, live vector vaccines, transgenic plant vaccines, and third generation vaccines, they play an important role in curbing the spread of PEDV.In recent years, research and development for PEDV vaccines has made remarkable achievements.This article aims to systematically review various types of PEDV vaccines and discuss the potential prospect for nanoparticle used in PEDV vaccines development, which will provide reference for the comprehensive prevention of PEDV.

关 键 词：猪流行性腹泻 α冠状病毒 疫苗 纳米颗粒 免疫 

分 类 号：S852.65[农业科学—基础兽医学]