短链脂肪酸对亚急性瘤胃酸中毒的影响和钠离子耦合单羧酸转运蛋白1和氢离子耦合单羧酸转运蛋白1对短链脂肪酸的转运机制  

Effects of Short Chain Fatty Acids on Subacute Ruminal Acidosis and Transport Mechanism of Sodium-Coupled MonocarboxylateTransporter 1 and Hydrogen-Coupled Monocarboxylate Transporter 1 on Short Chain Fatty Acids

作　　者：张剑霞 胡红莲 宋利文 高民 ZHANG Jianxia;HU Honglian;SONG Liwen;GAO Min(College of Animal Science,Inner Mongolia Agricultural University,Hohhot 010018,China;Institute of Animal Nutrition and Feed Science,Inner Mongolia Academy of Agricultural&Animal Husbandry Sciences,Hohhot 010031,China)

机构地区：[1]内蒙古农业大学动物科学学院,呼和浩特010018 [2]内蒙古自治区农牧业科学院动物营养与饲料研究所,呼和浩特010031

出　　处：《动物营养学报》2022年第12期7574-7584,共11页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：财政部和农业农村部——国家现代农业产业技术体系项目(CARS-36);内蒙古自治区科技计划项目(2021GG0028);呼和浩特科技计划项目(2020-科技兴蒙-国创中心-13)。

摘　　要：高精料饲粮在反刍动物瘤胃内经微生物发酵可产生大量短链脂肪酸(SCFA),使瘤胃内环境处于低pH状态,因此引起反刍动物亚急性瘤胃酸中毒(SARA)。在SARA发生时,SCFA不仅参与瘤胃上皮的糖、脂和能量代谢,还在维持黏膜屏障和减轻炎性反应等方面发挥重要调节作用,而单羧酸转运蛋白中的钠离子耦合单羧酸转运蛋白1(SLC5A8)与氢离子耦合单羧酸转运蛋白1(MCT1)负责瘤胃上皮内SCFA的转运与吸收,对于探究反刍动物发生SARA时,SLC5A8与MCT1基因的表达在SCFA转运机理上有重要意义。本文主要对SARA的定义、SCFA的调控机制以及SLC5A8、MCT1基因的表达与转运机制进行综述。High concentrate diet can produce a large amount of short chain fatty acids(SCFA)by microbial fermentation in the rumen of ruminants,which makes the rumen environment in a low pH state,thus causing subacute rumen acidosis(SARA)in ruminants.During SARA,SCFA is not only involved in glucose,lipid and energy metabolism in rumen epithelium,but also plays an important regulatory role in maintaining mucosal barrier and reducing inflammatory response.Sodium-coupled monocarboxylate transporter 1(SLC5A8)and hydrogen-coupled monocarboxylate transporter 1(MCT1)in monocarboxylate transporters are responsible for the transport and absorption of SCFA in rumen epithelium.The expression of SLC5A8 and MCT1 genes is of great significance in the mechanism of SCFA transport when SARA occurs in ruminants.This article mainly reviews the definition of SARA,the regulation mechanism of SCFA and the expression and transport mechanism of SLC5A8 and MCT1 genes.

关 键 词：亚急性瘤胃酸中毒 短链脂肪酸 SLC5A8基因 MCT1基因 

分 类 号：S816[农业科学—饲料科学]