小肠内排列术联合贝伐珠单抗对广泛黏连性肠梗阻的治疗效果及安全性分析  

Efficacy of plication of small intestine combined with bevacizumab in the treatment of extensive adhesive intestinal obstructionand its safety analysis

作　　者：马兵 Ma Bing(Department of general surgery,Minquan people's hospital,Shangqiu,Henan,476800,China)

机构地区：[1]民权县人民医院普外科,河南商丘476800

出　　处：《齐齐哈尔医学院学报》2022年第19期1845-1848,共4页Journal of Qiqihar Medical University

摘　　要：目的探讨小肠内排列术联合贝伐珠单抗治疗广泛黏连性肠梗阻(EAIO)的临床价值。方法选择2019年1月—2021年6月本院收治的EAIO患者70例作为研究对象,分为对照组与研究组两组,每组各35例。对照组接受小肠内排列术治疗,研究组接受小肠内排列术联合贝伐珠单抗治疗。比较两组手术前后的血清降钙素原(PCT)、淀粉样蛋白(SAA)、超敏C-反应蛋白(hs-CRP),比较两组的术后卧床时间、X线检查液气平面消失时间、术后通气时间、住院时间、术后6个月临床效果及并发症发生情况。结果术前两组的PCT(t=0.254)、hs-CRP(t=0.610)、SAA(t=0.515)水平差异无统计学意义(P>0.05)。术后1周研究组的PCT(t=8.320)、hs-CRP(t=3.127)、SAA(t=19.972)水平低于对照组,研究组的液气平面消失时间(t=4.153)、通气时间(t=2.167)、卧床时间(t=3.562)、住院时间(t=2.785)短于对照组,研究组的疗效优良率(94.29%Vs 77.14%)高于对照组,差异有统计学意义(P<0.05)。研究组与对照组的术后总并发症率(5.71%Vs 20.00%),差异无统计学意义(P>0.05)。结论小肠内排列术联合贝伐珠单抗治疗可促进EAIO患者术后身体康复,减轻患者腹腔炎症。Objective To investigate the clinical value of c combined with bevacizumab in the treatment of extensive adhesive intestinal obstruction(EAIO).Methods A total of 70 patients suffered with EAIO those were admitted to Minquan people's hospital from January 2019 to June 2021 were selected as the research subjects,and they were divided into the control group(35 cases,who received plication of small intestine)and the research group(35 cases,received plication of small intestine combined with bevacizumab)by random number table method.The serum procalcitonin(PCT),serumamyloid A(SAA)and high-sensitivity C-reactive protein(hs-CRP)levels were compared between the two groups before and after surgery.The bedding time,postoperative ventilation time,hospital stay,6-month postoperative clinical effect and complications were compared.Results There was no significant difference in the levels of PCT(t=0.254),hs-CRP(t=0.610)and SAA(t=0.515)between the two groups before surgery(P>0.05).One week after the operation,the levels of PCT(t=8.320),hs-CRP(t=3.127)and SAA(t=19.972)in the study group were lower than those in the control group.The time the liquid-gas plane disappears(t=2.167),bedtime(t=3.562)and hospital stay(t=2.785)were shorter than those in the control group,and the excellent and good rate of curative effect in the study group(94.29%Vs 77.14%)was higher than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the total postoperative complication rate between the study group and the control group(5.71%Vs 20.00%)(P>0.05).Conclusions Plication of small intestine combined with bevacizumab therapy could promote postoperative physical recovery in patients with EAIO and reduce abdominal inflammation.

关 键 词：广泛黏连性肠梗阻 小肠内排列术 贝伐珠单抗 炎性反应 

分 类 号：R656[医药卫生—外科学]