平乐郭氏验方对胫骨下段骨折愈合的影响  

Clinical Observation of Pingle Guoshi Recipe on Promoting the Healing of Distal Tibia Fractures

作　　者：李克军 胡敏杰[2] 陈佳旭[2] 刘芳芳[2] 袁海花 LI Ke-jun;HU Min-jie;CHEN Jia-xu(Hunan university of traditional Chinese medicine,Changsha,Hunan 410000)

机构地区：[1]湖南中医药大学,湖南长沙410000 [2]深圳平乐骨伤科医院-深圳市坪山区中医院

出　　处：《中国伤残医学》2022年第21期14-17,21,共5页Chinese Journal of Trauma and Disability Medicine

基　　金：深圳市坪山区卫生系统科研项目项目编号:201912。

摘　　要：要目的:平乐郭氏验方对腔骨下段骨折愈合的影响。方法:选取我院2019年1月-12月60例因胫骨下段骨折接受切开复位钢板螺钉内固定术后住院康复治疗的患者,将其随机分为观察组和对照组,每组各30例。术后2组患者均接受4周常规康复治疗,然后观察组患者开始在常规康复治疗基础上加用平乐郭氏验方(熟地壮骨合剂250ml,1剂/d,分早晚各温服1次,疗程为4周)。检测记录患者治疗前后总I型胶原氨基端延长肽(PINP)、β胶原系列(β-CTX)、骨钙素(N-MID)及胫腓骨下段X线等骨折愈合指标。结果:所有患者依从性较好,均按计划完成治疗。治疗后,2组患者在X线上均可见骨痴生长(P<0.05),且观察组较对照组骨痴生长更明显(P<0.05);观察组总有效率明显优于对照组(P<0.05);治疗后观察组患者骨合成指标总Ⅰ型胶原氨基端延长肽(PINP)、骨钙素(N-MID)水平明显高于对照组(P<0.05),抗再吸收指标β胶原系列(β-CTX)水平明显低于对照组患者(P<0.05)。结论:平乐郭氏验方促进胫骨下段骨折愈合的疗效显著且安全。Objective:To observe the clinical effects of Pingle Guoshi Recipe on the healing of distal tibia fractures.Methods:A total of eighty patients at Shenzhen Pingle orthopedics hospital were selected for this research,all sample patients have experienced distal tibia fractures and received open reduction and internal fixation(ORIF)with a locking plate.The sample patients were randomly divided into traditional Chinese medicine group and control group,with 30 cases in each group.After the operation,the patients in both groups received 4 weeks of regular rehabilitation treatment,while the patients in the traditional Chinese medicine group were further treated with 250 ml of Pingle Guoshi Recipe(Shu Di Zhuang Gu Mixture)per day by taking warm decoction each morning and each evening for a duration of four weeks.For the results,the research tested and recorded fracture healing indexes of both groups before and after treatment,including amino-terminal propeptide(PINP)of type Ⅰ collagen,β-Crosslaps(β-CTx),N-MID,and lower leg X-ray for Tibia and Fibula.Results:The patient compliance of both groups were good,all patients completed the treatment as planned.There was no statistically significant difference in general information between the two groups(P>0.05).After treatment,bone callus formation was seen on the X-ray in both groups(P<0.05),and the callus formation was more obvious in the treatment group than in the control group(P<0.05).The total effective rate of the Chinese medicine group was significantly better than that of the control group(P<0.05).After treatment,the level of amino-terminal propeptide(PINP)of type I collagen and N-MID in the traditional Chinese medicine group were significantly higher than those in the control group(P<0.05)and the level of anti-resorption indexβ-Crosslaps(β-CTx)was significantly lower than that of the control group(P<0.05).Conclusion:Pingle Guoshi Recipe is effective and safe in promoting the healing of distal tibia fractures.

关 键 词：胫骨下段骨折 平乐郭氏验方 骨折愈合 临床观察 

分 类 号：R683.42[医药卫生—骨科学]