铁死亡在膝骨关节炎性滑膜炎中的作用机制  

Mechanism of Ferroptosis in knee osteoarthritis synovitis

作　　者：宋永嘉 张增乔 翟天军 冯伟 SONG Yongjia;ZHANG Zengqiao;ZHAI Tianjun;FENG Wei(School of Rehabilitation Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学康复医学院,上海201203

出　　处：《生命的化学》2022年第10期1807-1812,共6页Chemistry of Life

基　　金：国家自然科学基金项目(81873328)。

摘　　要：铁死亡是一种新发现的细胞死亡形式,与多种疾病的发生密切相关,尤其在炎症反应方面具有重要的调控作用。膝关节滑膜炎(knee synovitis,KS)是膝骨关节炎(knee osteoarthritis,KOA)发病过程中重要的病理改变。KS造成的炎症微环境异常容易诱发铁死亡,而铁死亡又可通过触发机体非特异性免疫、脂氧合酶、环氧化产物等参与调节滑膜炎症反应,对KOA的发生发展、治疗及转归有着重要的影响。本文回顾了有关铁死亡在膝骨关节炎性滑膜炎作用机制方面的进展与突破,阐述了铁过载、铁死亡相关基因以及脂质过氧化物代谢与滑膜炎症的相关性,探讨了铁死亡在KOA中的潜在作用机制,以期为KOA的防治提供新的思路与方法。Ferroptosis, a newly discovered form of cell death, is closely associated with the development of several diseases and has an important regulatory role in the inflammatory response in particular. Knee synovitis(KS) is an important pathological change in the pathogenesis of knee osteoarthritis(KOA). The abnormal inflammatory microenvironment caused by KS can easily induce ferroptosis, which in turn can participate in regulating the synovial inflammatory response by triggering the body’s nonspecific immunity,lipoxygenase, and epoxidation products, and has an important impact on the development, treatment and regression of KOA. This article reviews the progress and breakthroughs in the mechanism of ferroptosis in osteoarthritic synovitis of the knee, describes the relevance of iron overload, ferroptosis-related genes and lipid peroxide metabolism to synovial inflammation, and explores the potential mechanism of ferroptosis in KOA,with the aim of providing new ideas and methods for the prevention and treatment of KOA.

关 键 词：膝骨关节炎 滑膜炎症 铁死亡 

分 类 号：R684.3[医药卫生—骨科学] R686.7[医药卫生—外科学]