“知信行”心理干预法与氟哌噻吨美利曲辛片药物治疗法对功能性消化不良伴轻度抑郁青年军人患者的疗效观察  

Observation on the Efficacy of"Knowledge,Trust and Action"Psychological Intervention Therapy versus Treatment with Flupentixol and Melitracen Tablets in Young Soldiers with Functional Dyspepsia Accompanying Mild Depression

作　　者：时荣海 王卉[1] 许爱丽 张霞[1] 赵敬敬 SHI Rong-hai;WANG Hui;XU Ai-li;ZHANG Xia;ZHAO Jing-jing(Hongshankou Outpatient Department,Jingbei Medical District,Chinese PLA General Hospital,Beijing 100091,China)

机构地区：[1]中国人民解放军总医院京北医疗区红山口门诊部,北京100091

出　　处：《中国合理用药探索》2022年第12期63-67,共5页Chinese Journal of Rational Drug Use

摘　　要：目的:对比采用“知信行”心理干预法和氟哌噻吨美利曲辛片治疗对功能性消化不良(FD)伴轻度抑郁的青年军人患者的临床疗效,探讨更为安全有效的治疗方式。方法:选取2018年6月~2021年12月本院门诊部收治的已在上级医院明确诊断为FD且经抑郁自评量表(SDS)评定为轻度抑郁(抑郁指数为0.5~0.59)、年龄在45岁以下的青年军人患者为研究对象,按照随机数字表法分为药物治疗组(n=33)与心理干预组(n=35)。药物治疗组给予氟哌噻吨美利曲辛片及消化道症状对症治疗药物,心理干预组给予“知信行”心理干预治疗及消化道症状对症治疗药物。观察两组患者的临床症状评分、抑郁指数及不良反应发生情况。结果:治疗8周后,两组临床症状评分均降低,但临床症状治疗有效率比较无统计学差异(P>0.05);两组抑郁指数均降低,但两组比较无统计学差异(P>0.05)。药物治疗组不良反应发生率(97.2%)高于心理干预组(2.9%,P<0.05)。结论:“知信行”心理干预法与氟哌噻吨美利曲辛片药物治疗FD伴轻度抑郁青年军人患者的临床有效性无统计学差异,但“知信行”心理干预法的不良反应发生率更低,更为安全有效。建议军队加强对青年军人的心理健康教育及干预。Objective:Compare the clinical efficacy of"Knowledge,Trust and Action"psychological intervention therapy and therapy of flupentixol and melitracen tablets in young soldiers with functional dyspepsia(FD)accompanying mild depression and to explore a safer and more effective treatment method.Methods:68 young soldiers(≤45 years old)who received outpatient service by our department from June 2018 to December 2021 and had been definitely diagnosed with FD in a superior hospital and assessed as mild by the self-rating depression scale(SDS)were selected as the study subjects.They were randomly divided into two groups.The treatment group was given flupentixol and melitracen tablets and symptomatic treatment of digestive tract symptoms,and the psychological intervention group was given"knowledge,trust and action"psychological intervention treatment and symptomatic treatment of digestive tract symptoms.The changes of clinical symptom score and SDS depression index and the incidence rate of adverse drug reactions in the two groups were observed.Results:Eight weeks after treatment,the clinical symptom scores of the two groups decreased,and no significant difference in the response rate of clinical symptom improvement between the two groups was observed(P>0.05).The depression index in both groups decreased,and the response rate of depression treatment was not statistically significant between the two groups(P>0.05).The incidence of adverse drug reactions in the psychological intervention group was 2.9%,and the incidence of adverse reactions in the treatment group was 97.2%.There was a significant difference between the two groups(P<0.05).Conclusion:There is no statistically significant difference in clinical efficacy between the psychological intervention method of"Knowledge,Trust and Action"and the treatment with flupentixol and melitracen tablets in young soldiers with FD accompanying mild depression.However,the"Knowledge,Trust and Action"psychological intervention method may cause quite few adverse reactions,it is safe an

关 键 词：心理干预 氟哌噻吨美利曲辛片 药物治疗 青年军人 功能性消化不良 轻度抑郁 

分 类 号：R541.6[医药卫生—心血管疾病]