浮针围刺法治疗难愈性压疮疗效观察及对患者血清SOD、MDA、IGF-1水平的影响  

Effect of floating acupuncture therapy on refractory pressure ulcer and its effects on serum levels of superoxide dismutase, malondialdehyde and insulin-like growth factor-1

作　　者：赵柔刚 傅建明 傅晓倩 曹小英 傅雄伟 李小龙 Zhao Rougang;Fu Jianming;Fu Xiaoqian;Cao Xiaoying;Fu Xiongwei;Li Xiaolong(Rehabilitation Medical Center,The Second Hospital of Jiaxing,Jiaxing 314000,Zhejiang Province,China)

机构地区：[1]嘉兴市第二医院康复医学中心,嘉兴314000

出　　处：《中国基层医药》2022年第11期1644-1647,共4页Chinese Journal of Primary Medicine and Pharmacy

基　　金：浙江省嘉兴市科技计划项目(2018AD32006)。

摘　　要：目的探讨浮针围刺法治疗难愈性压疮临床疗效及对患者血清超氧化物歧化酶(SOD)、丙二醛(MDA)和胰岛素样生长因子1(IGF-1)水平的影响。方法选取嘉兴市第二医院2019年10月至2021年10月收治的难愈性压疮患者60例为研究对象,采用随机对照研究方法,以随机数字表法将入选者分为观察组30例、对照组30例。对照组采用常规治疗;观察组在常规治疗基础上给予浮针围刺法治疗。比较两组临床疗效,治疗7 d、14 d和21 d创面愈合率,新生肉芽出现时间、腐肉脱落时间和创面愈合时间,治疗前和治疗21 d血清SOD、MDA和IGF-1水平变化。结果观察组总有效率为90.0%(27/30),高于对照组的66.7%(20/30)(χ^(2)=4.81,P<0.05)。观察组治疗7 d、14 d、21 d创面愈合率均高于对照组(t=-5.45、-7.77、-7.51,均P<0.001)。观察组新生肉芽出现时间、腐肉脱落时间、创面愈合时间均短于对照组(t=5.69、9.26、8.91,均P<0.001)。治疗21 d,观察组血清SOD、MDA、IGF-1分别为(96.52±10.43)U/mL、(4.32±0.78)μmol/L、(43.52±8.29)μg/L,对照组分别为(83.76±6.81)U/mL、(5.48±0.92)μmol/L、(36.78±9.18)μg/L,两组比较,差异均有统计学意义(t=5.61、5.27、2.98,均P<0.05)。结论浮针围刺法治疗难愈性压疮的疗效良好,可加快患者创面愈合,提高SOD和IGF-1水平,降低MDA水平。Objective To investigate the efficacy of floating acupuncture therapy in the treatment of chronic refractory pressure ulcers and its effects on serum levels of superoxide dismutase,malondialdehyde and insulin-like growth factor-1.Methods A total of 60 patients with chronic refractory pressure ulcers who received treatment in The Second Hospital of Jiaxing from October 2019 to October 2021 were included in this study.They were randomly divided into observation and control groups,with 30 patients in each group.The patients in the control group were given routine treatment,while the patients in the observation group were given floating acupuncture therapy based on routine treatment.Clinical efficacy,wound healing rate after 7,14 and 21 days of treatment,the time of emerging granulation tissue,the time of shedding rotten meat,and the time of wound healing,changes in serum levels of superoxide dismutase,malondialdehyde and insulin-like growth factor-1 after 21 days of treatment relative to those before treatment were compared between the two groups.Results Total response rate in the observation group was significantly higher than that in the control group[90.0%(27/30)vs.66.7%(20/30),χ^(2)=4.81,P<0.05].Wound healing rate after 7,14 and 21 days of treatment in the observation group was significantly higher than that in the control group(t=-5.45,-7.77,-7.51,all P<0.001).The time of emerging granulation tissue,the time of shedding rotten meat,and the time of wound healing in the observation group were significantly shorter than those in the control group(t=5.69,9.26,8.91,all P<0.001).After 21 days of treatment,serum levels of superoxide dismutase,malondialdehyde and insulin-like growth factor-1 in the observation group were(96.52±10.43)U/mL,(4.32±0.78)μmol/L,(43.52±8.29)μg/L,respectively,which were significantly different from(83.76±6.81)U/mL,(5.48±0.92)μmol/L,(36.78±9.18)ng/mL,in the control group(t=5.61,5.27,2.98,all P<0.05).Conclusion Floating acupuncture therapy is effective in the treatment of refractory pr

关 键 词：针刺疗法 压力性溃疡 伤口愈合 肉芽组织 超氧化物歧化酶 丙二醛 胰岛素样生长因子Ⅰ 

分 类 号：R246.2[医药卫生—针灸推拿学]