深Ⅱ~Ⅲ度烧伤早期中性粒细胞趋化功能与趋化因子受体的关系研究  

Relationship between neutrophil chemotactic function and chemokine receptor in the early stage of deep second- and third-degree burns

作　　者：林卫 张慧英[2] 刘先奇 Lin Wei;Zhang Huiying;Liu Xianqi(Department of Burn and Plastic Surgery,Yantai Yeda Hospital,Yantai 264006,Shandong Province,China;Veteran Cadres Section,Yantai Yuhuangding Hospital,Yantai 264006,Shandong Province,China)

机构地区：[1]烟台业达医院烧伤整形科,烟台264006 [2]烟台毓璜顶医院老干部科,烟台264006

出　　处：《中国基层医药》2022年第11期1696-1699,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨深Ⅱ~Ⅲ度烧伤早期中性粒细胞(NEU)趋化功能与趋化因子受体(CXCR)的关系。方法选取烟台业达医院2019年1月至2020年6月收治的烧伤后6 h内入院的严重烧伤患者(烧伤组)和体检健康者(体检健康组)各20例,分析两组一般资料和实验室检查指标,评价NEU趋化功能与CXCR的相关性。结果两组一般资料差异无统计学意义(P>0.05);烧伤组入院后1、3、5 d的NEU计数、白细胞计数(WBC)、降钙素原(PCT)、C反应蛋白(CRP)、白细胞介素(IL)6、IL-10及肿瘤坏死因子α(TNF-α)均显著高于体检健康组(F=12.56、13.45、15.78、17.83、22.56、13.39、10.82,均P<0.05);烧伤组入院后1、3、5 d的NEU趋化距离分别为(1510.22±108.45)μm、(1380.90±115.67)μm、(1026.10±95.48)μm,均显著短于体检健康组的(1944.67±139.20)μm(t=23.44、25.67、27.52,均P<0.05);烧伤组入院后5 d,CXCR1、CXCR2阳性率分别为(47.40±1.76)%、(75.33±2.42)%,均显著低于体检健康组的(95.24±4.89)%、(97.78±2.10)%(t=4.92、5.67,均P<0.05);相关性分析结果显示,深Ⅱ~Ⅲ度烧伤患者NEU趋化距离与CXCR表达呈正相关(r=0.72、0.61,均P<0.05)。结论深Ⅱ~Ⅲ度烧伤早期NEU趋化功能降低与CXCR表达下降有关。Objective To investigate the relationship between neutrophil chemotactic function and chemokine receptor in the early stage of deep second-and third-degree burns.Methods Twenty patients with severe burns(burn group)who received treatment within 6 hours after burns in Yantai Yeda Hospital from January 2019 to June 2020 were included in this study.Twenty healthy controls(healthy group)who concurrently received physical examination in the same hospital were also included.The general data and laboratory examination indexes in each group were analyzed.The correlation between neutrophil chemotactic function and chemokine receptor was evaluated.Results There were no significant differences in general data between the two groups(all P>0.05).At 1,3 and 5 days after admission,the number of neutrophils,the number of white blood cells,and procalcitonin,C-reactive protein,interleukin-6,interleukin-10,and tumor necrosis factor-αlevels in the burn group were significantly higher than those in the healthy control groups(F=12.56,13.45,15.78,17.83,22.56,13.39,10.82,all P<0.05).At 1,3 and 5 days after admission,neutrophil migration distance in the burn group was(1510.22±108.45)μm,(1380.90±115.67)μm,(1026.10±95.48)μm,respectively,which were significantly shorter than(1944.67±139.20)μM in the healthy control group(t=23.44,25.67,27.52,all P<0.05).At 5 days after admission,chemokine receptors 1 and 2 positive rates in the burn group were(47.40±1.76)%and(75.33±2.42)%,respectively,which were significantly lower than(95.24±4.89)%and(97.78±2.10)%in the healthy control groups(t=4.92,5.67,both P<0.05).Correlation analysis showed that neutrophil migration distance was positively correlated with chemokine receptor expression in patients with deep second-and third-degree burns(r=0.72,0.61,both P<0.05).Conclusion Neutrophil chemotactic function and chemokine receptor expression decrease in the early stage of deep second-and third-degree burns.

关 键 词：烧伤 中性白细胞 中性白细胞浸润 炎症趋化因子类 趋化作用 趋化因子类 受体 趋化因子 

分 类 号：R644[医药卫生—外科学]