南通地区体检人群血清尿酸/肌酐比值与代谢综合征的相关性研究  

Correlation between serum uric acid and creatinine ratio and metabolic syndrome based on physical examination population in Nantong area

作　　者：保方[1] 王英 鞠少卿[1] 孙文杰 李妍慧 张云骋 孙晓烨[3] 蒋晨[3] 丛辉[1] Bao Fang;Wang Ying;Ju Shaoqing;Sun Wenjie;Li Yanhui;Zhang Yuncheng;Sun Xiaoye;Jiang Chen;Cong Hui(Department of Laboratory Medicine,Affiliated Hospital of Nantong University,Nantong 226001,China;School of Public Health,Nantong University,Nantong 226019,China;Department of Blood Transfusion,Affiliated Hospital of Nantong University,Nantong 226001,China)

机构地区：[1]南通大学附属医院医学检验科,南通226001 [2]南通大学公共卫生学院,南通226019 [3]南通大学附属医院输血科,南通226001

出　　处：《中华预防医学杂志》2022年第11期1630-1635,共6页Chinese Journal of Preventive Medicine

基　　金：江苏省六大人才资助(WS-066);南通市科学技术局项目(MSZ2022077,MS12020007);江苏省大学生创新计划重点项目(202210304050Z)。

摘　　要：探讨南通地区体检人群血清尿酸/肌酐比值(SUA/Cr)与代谢综合征(MS)以及其他指标的关联性。采用横断面研究的方法,以2017年1月至2020年4月在南通大学附属医院体检中心的8148名体检者作为研究对象,收集研究对象的烟酒嗜好、体格检查等临床资料和血清生化指标。采用中华医学会糖尿病分会的标准诊断MS,按SUA/Cr的四分位数分组并比较各组间临床资料,分别采用Pearson相关分析、logistic回归分析对SUA/Cr与各临床指标的相关性、SUA/Cr与MS患病风险的关系进行统计学分析。结果显示,UA、SUA/Cr在代谢正常组最低,代谢异常组其次,MS组最高,两两组间比较差异均有统计学意义(H=919.21和629.34,P均<0.001)。根据SUA/Cr四分位数将人群分为四组,校正性别、年龄、吸烟史以及饮酒史后,Q1组SUA/Cr与BMI、TG呈正相关(r=0.061和0.080,P均<0.05),与HDL-C呈负相关(r=-0.057,P<0.05)。多因素logistic回归结果显示,在校正年龄、性别、吸烟史、饮酒史后,BMI、SBP、DBP、FBG、TG、HDL-C和SUA/Cr等指标发生MS的风险性[OR(95%CI)]分别为:1.44(1.41-1.47)、1.07(1.06-1.07)、1.10(1.10-1.11)、1.83(1.73-1.92)、1.89(1.79-1.99)、0.08(0.06-0.10)和1.54(1.47-1.62)。与SUA/Cr的Q1组相比,Q_(2)、Q_(3)、Q_(4)组的MS发生风险分别增加75%、162%、346%。综上,南通地区体检人群SUA/Cr与MS患病风险可能呈独立正相关。To investigate the relationship between serum uric acid to creatinine ratio(SUA/Cr)and metabolic syndrome(MS)and other indexes on physical examination population in Nantong area.Using the method of cross-sectional study,8148 physical examiners in the physical examination center of the Affiliated Hospital of Nantong University from January 2017 to April 2020 were used as the research objects,and the clinical data and serum biochemical indicators such as smoking and alcohol addiction,physical examination and so on were collected.According to the standard diagnosis of MS of Diabetes Society of Chinese Medical Association,the patients were grouped according to the quartile of SUA/Cr and the clinical data of each group were compared.Pearson correlation analysis and logistic regression analysis were used to explore the correlation between SUA/Cr and clinical indicators and the relationship between SUA/Cr and the risk of MS.The results showed that UA and SUA/Cr were the lowest in normal metabolism group,followed by abnormal metabolism group and the highest in MS group,The difference between the two groups was statistically significant(H=919.21 and 629.34,P<0.001).According to the SUA/Cr quartile,the population was divided into four groups.After adjusting for gender,age,smoking history and drinking history,SUA/Cr in group Q1 was positively correlated with BMI and TG(r=0.061 and 0.080,P<0.05),but negatively correlated with HDL-C(r=-0.057,P<0.05).Multivariate logistic regression results showed that after adjusting for age,sex,smoking history and drinking history,the risk of MS for BMI,SBP,DBP,FBG,TG,HDL-C and SUA/Cr[OR(95%CI)]were:1.44(1.41-1.47),1.07(1.06-1.07),1.10(1.10-1.11),1.83(1.73-1.92),1.89(1.79-1.99),0.08(0.06-0.10)and 1.54(1.47-1.62).Compared with SUA/Cr group Q1,the risk of MS in group Q2,Q3 and Q4 increased by 75%,162%and 346%,respectively.In conclusion,there was an independent positive correlation between SUA/Cr and MS risk in Nantong area.

关 键 词：尿酸 肌酐 代谢综合征 尿酸/肌酐 体检人群 

分 类 号：R446.1[医药卫生—诊断学] R589[医药卫生—临床医学]