液相色谱串联质谱技术在精准医疗中的应用进展  

Application progress of liquid chromatography tandem mass spectrometry in precision medicine

作　　者：金静怡 裘福荣 张珏[2] Jin Jingyi;Qiu Furong;Zhang Jue(Laboratory of Clinical Pharmacokinetics,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Department of Clinical Laboratory,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院临床药代动力学实验室,上海201203 [2]上海中医药大学附属曙光医院检验科,上海201203

出　　处：《中华预防医学杂志》2022年第11期1675-1684,共10页Chinese Journal of Preventive Medicine

基　　金：国家自然科学基金(81874364);上海中医药大学附属曙光医院四明青年基金(SGKJ-202019)。

摘　　要：液相色谱串联质谱技术(LC-MS/MS)是结合液相高分离与质谱高选择及高灵敏的一种分析方法。近年来,LC-MS/MS广泛应用于临床实践,包括先天性疾病筛查、内源性化合物水平测定、生物标志物分析等方面。因LC-MS/MS可提供准确的数据,所以对临床某些疾病的精准预防及诊治具有重要价值。本文阐述LC-MS/MS在精准医疗中的应用优势,并展望其在临床实践中的未来前景,以期推动临床LC-MS/MS技术在疾病预防和诊治中的发展。Liquid chromatography tandem mass spectrometry(LC-MS/MS)is an analytical method that combines high separation of liquid chromatography with high selectivity and sensitivity of mass spectrometry.In recent years,LC-MS/MS has been widely used in clinical practice,including screening of inherited disorders,determination of endogenous compounds and analysis of biomarkers.LC-MS/MS is of great value to the precision prevention,diagnosis and treatment of some diseases due to its accurate data.This article not only illustrates the advantages of LC-MS/MS in precision medicine,but also prospects the future trend of LC-MS/MS in clinical practice,which expects to promote the development of clinical LC-MS/MS in the prevention,diagnosis and treatment of diseases.

关 键 词：精准医疗 遗传性疾病 先天性 生物标志物 液相色谱串联质谱 内源性物质 

分 类 号：O657.63[理学—分析化学] R313[理学—化学]