益气活血类中成药改善冠状动脉粥样硬化性心脏病患者内皮保护功能的系统评价  

A systematic review on the improving effects of Chinese patent medicine for supplementing Qi and activating blood circulation on endothelial protection function in coronary heart disease patients

作　　者：张程 苏文革[2] 冯楚涵 田颖[2] ZHANG Cheng

机构地区：[1]山东中医药大学第一临床医学院,山东济南250014 [2]山东中医药大学附属医院&高血压国家中医临床研究基地,山东济南250014 [3]山东中医药大学中医学院,山东济南250014

出　　处：《中医临床研究》2022年第32期67-72,共6页Clinical Journal Of Chinese Medicine

基　　金：山东省科技创新基地专项[鲁财科教指(2019)30号]。

摘　　要：目的:系统评价益气活血类中成药改善冠状动脉粥样硬化性心脏病(简称冠心病)患者内皮保护功能的疗效。方法:在中国知网、万方数据库、中文科技期刊全文数据库、PubMed、Embase数据库、Cochrane图书馆等数据库检索所有已上市的益气活血类中成药治疗冠心病的随机对照试验。评估筛选后的文献质量,提取文献数据,对纳入的临床试验进行Cochrane风险偏倚评价系统风险偏倚评估,进行Meta分析,并使用RevMAan 5.3软件进行质量评价。结果:Meta分析显示,益气活血类中成药可升高血浆一氧化氮(Nitric Oxide,NO)水平(P<0.00001),降低内皮素(Endothelin,ET)水平(P<0.0001),改善肱动脉介导的内皮依赖性舒张功能。结论:益气活血类中成药可升高冠心病患者的血浆NO水平,降低血浆ET水平,改善内皮依赖性舒张功能,改善内皮细胞功能。Objective:To systematically evaluate the improving efficacy of Chinese patent medicine for supplementing Qi(气)and activating blood circulation on endothelial protection function of coronary heart disease patients.Methods:In databases such as CNKI,Wanfang database,VIP database,PubMed,Embase Database,Cochrane Library,all the randomized controlled trials of Chinese patent medicines on sale for supplementing Qi and activating blood circulation in the treatment of coronary heart disease were searched,and the qualities of the included studies were evaluated.The data of the included studies was extracted.Cochrane risk bias evaluation system was used to perform a risk bias evaluation for the included clinical trials.A meta-analysis was executed,and RevMan 5.3 software was used for a quality evaluation.Results:The results of the meta-analysis showed that Chinese patent medicines for supplementing Qi and activating blood circulation can increase plasma nitric oxide level(P<0.00001),decrease plasma endothelin level(P<0.0001),and improve endothelial dependent relaxation function mediated by brachial artery.Conclusion:Chinese patent medicine for supplementing Qi and activating blood circulation can increase plasma nitric oxide level,decrease plasma endothelin level,improve endothelial dependent relaxation function,and improve endothelial cell function of the coronary heart disease patient.

关 键 词：冠状动脉粥样硬化性心脏病 益气活血类中成药 Meta分析 随机对照试验 内皮细胞功能 

分 类 号：R256.2[医药卫生—中医内科学]