主动脉夹层组织中载脂蛋白H表达变化及其临床意义  

Clinical significance of ApoH expression in aortic dissection

作　　者：冯鑫 何毅 肖杰文[1] 蒋丁胜 魏翔[1] FENG Xin;HEYi;XIAO Jiewen(Divison of Cardiothoracic and Vascular Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院心脏大血管外科,武汉430030

出　　处：《临床外科杂志》2022年第10期970-972,共3页Journal of Clinical Surgery

基　　金：国家自然科学基金(81670050)。

摘　　要：目的探讨主动脉夹层中载脂蛋白H(ApoH)的表达变化及其临床意义。方法2015年8月~2020年1月我院收治Stanford A型主动脉夹层病人15例,手术中剪取的升主动脉组织作为夹层组。9例心脏移植或心肺移植病人术中修剪的正常升主动脉壁作为对照组。检测ApoH蛋白在两组组织样本中表达量的变化,采用Pearson相关分析法对ApoH蛋白水平和主动脉夹层病人主动脉直径之间的相关性进行分析。结果夹层组主动脉壁中ApoH蛋白的表达水平高于对照组,两组比较差异有统计学意义(P<0.05),但其蛋白表达量与主动脉夹层病人的主动脉直径变化无相关性(P>0.05)。结论ApoH蛋白表达水平在主动脉夹层病人主动脉壁中偏高,提示ApoH可能参与主动脉夹层形成,靶向ApoH有可能成为延缓主动脉夹层的潜在策略。Objective To explore the expression change and clinical implication of apolipoprotein H(ApoH)in aortic dissection(AD).Methods Fifteen patients with Stanford type A aortic dissection(TAAD)in Tongji Hospital from August 2015 to January 2020 were included,and the ascending aortic tissue extracted during the operation was used as the TAAD group.Normal ascending aortic wall clipped during heart transplantation or cardiopulmonary transplantation was selected as the control group(9 cases).The protein levels of ApoH were detected in the two groups,and Pearson correlation analysis was used to analyze the relationship between the protein levels of ApoH and the aortic diameters of patients with TAAD.Results Western blot and immunohistochemical staining showed that the expression levels of ApoH in the aortic wall of TAAD group was significantly higher than that of the control group(P<0.05).However,there was no significant correlation between the protein levels of ApoH and the aortic diameters of TAAD(P>0.05).Conclusion The protein expression of ApoH is significantly upregulated in aortic wall of patients with TAAD,suggesting that ApoH may be involved in the pathogenesis of AD.Targeting ApoH may be a potential new strategy for delaying AD.

关 键 词：主动脉夹层 载脂蛋白H 脂代谢紊乱 

分 类 号：R654.3[医药卫生—外科学]