季节性流感病毒与其他病原混合或继发感染的研究进展与思考  

Coinfection and secondary infection of seasonal influenza virus with other pathogens:a review

作　　者：路雅菲 薛江东[1] 毕玉海[2,3] LU Yafei;XUE Jiangdong;BI Yuhai(College of Animal Science and Technology,Inner Mongolia Minzu University,Tongliao 021400,Inner Mongolia,China;CAS Key Laboratory of Pathogenic Microbiology and Immunology,Institute of Microbiology,Center for Influenza Research and Early-Warning(CASCIRE),Chinese Academy of Sciences,Beijing 100101,China;University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]内蒙古民族大学动物科技学院,内蒙古通辽021400 [2]中国科学院流感研究与预警中心,中国科学院微生物研究所,病原微生物与免疫学重点实验室,北京100101 [3]中国科学院大学,北京100049

出　　处：《微生物学报》2022年第12期4731-4739,共9页Acta Microbiologica Sinica

基　　金：北京市自然科学基金-海淀原始创新联合基金(L192007);内蒙古自治区自然科学基金(2018LH03016);国家自然科学基金(31660726,31870163);国家中医药管理局急性呼吸道感染及新发呼吸道传染病中西医结合创新团队(ZYYCXTD-D-202208);中国科学院青年创新促进会(Y2021034);国家科技资源共享服务平台项目(国家病原微生物资源库-NPRC-32)。

摘　　要：流感病毒包括甲(A)、乙(B)、丙(C)和丁(D)四种型。人流行性感冒是由甲型和乙型季节性流感病毒引起的一种急性呼吸道传染病。流感病毒感染患者主要表现出呼吸道症状,严重时可以导致肺炎。此外,与其他病毒、细菌和支原体等病原体混合或继发感染时,会增加流感患者的重症率和死亡率。近几年,流感病毒与其他病原协同感染的病例有增加趋势。本文归纳总结了流感病毒与其他病原混合及继发感染的研究现状,希望为流感病毒复杂感染情况的临床诊断和治疗方案的制定提供线索。Human influenza is an acute respiratory infectious disease caused by influenza virus.Among the four types(A,B,C,and D)of influenza virus,influenza A and B viruses are the common pathogens causing human influenza.The patients with influenza virus infections mainly have respiratory syndromes and severe cases usually develop into pneumonia.In addition,the severe cases and mortality will increase in the case of coinfection or secondary infection of influenza virus with other pathogens(other viruses,bacteria,Mycoplasma,etc.).There has been an increasing trend of coinfections caused by influenza virus together with other pathogens.In this review,we briefly described the research progress in coinfections and secondary infections of influenza A or B virus with other pathogens,aiming to support the diagnosis and treatment of the complicated infections.

关 键 词：流感病毒 病原 混合感染 继发感染 

分 类 号：R511.7[医药卫生—内科学]