Excitatory Crossmodal Input to a Widespread Population of Primary Sensory Cortical Neurons  

作　　者：Yuan-Jie Xiao Lidan Wang Yu-Zhang Liu Jiayu Chen Haoyu Zhang Yan Gao Hua He Zheng Zhao Zhiru Wang 

机构地区：[1]Institute and Key Laboratory of Brain Functional Genomics of the Chinese Ministry of Education,Shanghai Key Laboratory of Brain Functional Genomics,School of Life Sciences,East China Normal University,Shanghai,200062,China [2]Department of Neurosurgery,Third Affiliated Hospital of the Navy Military Medical University,Shanghai,200438,China [3]Department of Neuroscience,University of Pittsburgh,Pittsburgh,15260,USA

出　　处：《Neuroscience Bulletin》2022年第10期1139-1152,共14页神经科学通报（英文版）

基　　金：This work was supported by grants from the National Natural Science Foundation of China(31970957 and 31471078);the Shanghai Science and Technology Commission(19ZR1416600);funding from 2021-JCJQ-JJ-1089.

摘　　要：Crossmodal information processing in sensory cortices has been reported in sparsely distributed neurons under normal conditions and can undergo experience-or activity-induced plasticity.Given the potential role in brain function as indicated by previous reports,crossmodal connectivity in the sensory cortex needs to be further explored.Using perforated whole-cell recording in anesthetized adult rats,we found that almost all neurons recorded in the primary somatosensory,auditory,and visual cortices exhibited significant membrane-potential responses to crossmodal stimulation,as recorded when brain activity states were pharmacologically down-regulated in light anesthesia.These crossmodal cortical responses were excitatory and subthreshold,and further seemed to be relayed primarily by the sensory thalamus,but not the sensory cortex,of the stimulated modality.Our experiments indicate a sensory cortical presence of widespread excitatory crossmodal inputs,which might play roles in brain functions involving crossmodal information processing or plasticity.

关 键 词：Crossmodal input Crossmodal response Crossmodal plasticity Sensory cortex Crossmodal task Sensory loss GABAergic transmission 

分 类 号：R338[医药卫生—人体生理学]