2020年辽宁省不同年龄组健康人群麻疹、风疹、流行性腮腺炎抗体血清学分析  

Serological analysis on antibody levels to measles,rubella and mumps in healthy people in different age groups in Liaoning,2020

作　　者：王文思[1] 安晓慧[1] 朱丽君[2] 赵玲[3] 韩立新[4] 方兴[1] 王艳[1] Wang Wensi;An Xiaohui;Zhu Lijun;Zhao Ling;Han Lixin;Fang Xing;Wang Yan(Liaoning Provincial Center for Disease Control and Prevention,Shenyang 110005,Liaoning,China;Shenyang Municipal Center for Disease Control and Prevention,Shenyang 110031,Liaoning,China;Dandong Prefectural Center for Disease Control and Prevention,Dandong 118002,Liaoning,China;Fuxin Prefectural Center for Disease Control and Prevention,Fuxin 123000,Liaoning,China)

机构地区：[1]辽宁省疾病预防控制中心,辽宁沈阳110005 [2]沈阳市疾病预防控制中心,辽宁沈阳110031 [3]丹东市疾病预防控制中心,辽宁丹东118002 [4]阜新市疾病预防控制中心,辽宁阜新123000

出　　处：《疾病监测》2022年第10期1290-1293,共4页Disease Surveillance

基　　金：辽宁省流行麻疹和风疹野病毒全基因测序技术建立及基因变异变迁规律研究(No.2020MS357)。

摘　　要：目的了解辽宁省扩大免疫规划实施10年后不同年龄组健康人群麻疹、风疹及流行性腮腺炎IgG抗体水平,为及时发现免疫薄弱人群,采取针对性免疫措施提供依据。方法采用单纯随机抽样方法采集辽宁省3个地市6个县(区)共计498名健康人群血标本,使用酶联免疫吸附试验检测血清中麻疹、风疹及流行性腮腺炎IgG抗体,分析抗体阳性率和几何平均浓度(GMC)。结果本次监测麻疹抗体阳性率为94.78%,GMC为851.10 m IU/m L;风疹抗体阳性率为87.15%,GMC为40.90 IU/m L;流行性腮腺炎抗体阳性率为90.16%,GMC为330.93 U/mL。不同地区麻疹、风疹及流行性腮腺炎IgG抗体阳性率和GMC水平差异均有统计学意义(P<0.01);不同年龄组麻疹GMC水平、风疹及流行性腮腺炎IgG抗体阳性率和GMC水平差异有统计学意义(P<0.01),但麻疹IgG抗体阳性率差异无统计学意义(P>0.05);不同性别间麻疹、风疹及流行性腮腺炎IgG抗体阳性率和GMC水平差异无统计学意义(P>0.05)。结论辽宁省麻疹和流行性腮腺炎IgG抗体水平较高,风疹IgG抗体水平较低。儿童和青少年抗体水平呈现随疫苗接种时间的推移而下降的趋势,建议加强青少年组人群针对性免疫策略。Objective To investigate the IgG antibody levels to measles,rubella and mumps in healthy people in different age groups ten years after the implementation of the Expanded Immunization Program in Liaoning province,and provide Evidence for the timely detection of immune vulnerable groups and targeted immunization measures.Methods A total of 498healthy people’s blood samples were collected from monitoring sites in 6 counties of 3 cities in Liaoning by random sampling method.Serum IgG antibodies were detected by enzyme-linked immunosorbent assay for measles,rubella and mumps,and the positive rate and geometric mean concentration(GMC)of antibodies were analyzed.Results The positive rate of measles antibody was 94.78%,and the GMC was 851.10 mIU/mL;the positive rate of rubella antibody was 87.15%,and the GMC was40.90 IU/mL;the positive rate of mumps antibody was 90.16%,and the GMC was 330.93 U/mL.The differences in positive rates and GMC levels of measles,rubella and mumps were significant among different areas(P<0.01).The differences in GMC level of measles,the positive rate of rubella and mumps IgG antibody and GMC level were significant among different age groups(P<0.01),but there was no significant difference in the positive rate of measles IgG antibody(P>0.05),and there were no gender specific statistical differences in the positive rate of measles,rubella and mumps IgG antibody and GMC levels(P>0.05).Conclusion The levels of IgG antibody to measles and mumps were high in Liaoning,but the level of IgG antibody to rubella was low.Antibody levels in children and adolescents decreased over time after vaccination,and so the targeted immunization strategies should be strengthened in adolescents.

关 键 词：麻疹 风疹 流行性腮腺炎 抗体水平 

分 类 号：R211[医药卫生—中医学] R186