2018-2020年江苏省健康人群麻疹抗体水平监测分析  

Analysis on measles antibody level in healthy population in Jiangsu,2018-2020

作　　者：胡莹[1] 陆培善[1] 邓秀英[1] 郭宏雄[1] Hu Ying;Lu Peishan;Deng Xiuying;Guo Hongxiong(Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009,Jiangsu,China)

机构地区：[1]江苏省疾病预防控制中心,江苏南京210009

出　　处：《疾病监测》2022年第10期1299-1303,共5页Disease Surveillance

摘　　要：目的了解和掌握2018—2020年江苏省不同年龄组健康人群的麻疹免疫情况,对其麻疹抗体水平进行监测,并结合近年麻疹发病情况,为麻疹消除提供依据。方法选择2018—2020年江苏省7个市/县的健康人群,按年龄分为0~7月龄、8月龄至4岁、5~14岁、15~24岁、25~39岁、40~60岁共6个组。使用酶联免疫吸附试验(ELISA)检测麻疹IgG抗体并进行定量换算,计算其抗体阳性率、高浓度抗体率、几何平均浓度(GMC)。结果共检测标本3132份,抽样人群的抗体阳性率为79.25%,GMC为491.02 mIU/mL,高浓度抗体样品1267份,占40.45%。具有1~4剂次含麻疹成分疫苗接种史的人群中,IgG抗体阳性率为90.34%,GMC为741.31 mIU/mL。各年龄组之间麻疹IgG抗体阳性率和GMC差异有统计学意义(χ^(2)=687.192,P<0.001;F=174.734,P<0.001)。不同地区麻疹IgG抗体以及GMC差异有统计学意义(χ^(2)=72.545,P<0.001;F=19.946,P<0.001)。结论江苏省健康人群的麻疹抗体阳性率较高,发生大范围暴发或流行的风险较低,但个别地区个别年龄组人群抗体阳性率较低,需加强免疫。结合江苏省现有麻疹发病情况,不需调整现有免疫策略。Objective To understand the measles immunization status of healthy population in different age groups in Jiangsu province,monitor the antibody level to measles,analyze the incidence of measles,and provide evidence for the elimination of measles.Methods From 2018 to 2020,the healthy population in seven cities of Jiangsu was selected and divided into six groups,0−7 month,8 months−4 years,5−14 years,15−24 years,25−39 years,40−60 years.Measles IgG was detected by ELISA.The antibody positive rate,high concentration antibody rate and geometric mean concentration(GMC)of measles IgG were calculated.Results A total of 3132 samples were detected.The overall measles positive rate was 79.25%,the overall GMC was 491.02 mIU/mL and 1267 samples(40.45%)had high concentration of antibody.The positive rate of IgG and GMC were 90.34%and 741.31 mIU/mL in the population with 1−4 doses of measles containing vaccine immunization.There were statistical significant differences in antibody positive rate and GMC among age groups(χ^(2)=687.192,P<0.001;F=174.734,P<0.001).There were statistical significant difference in measles antibody and GMC among different areas(χ^(2)=72.545,P<0.001;F=19.946,P<0.001).Conclusion The positive rate of measles in healthy population in Jiangsu is high,and the risk for large-scale measles epidemic is low.But the positive rates in some age groups in some areas are low.So the measles immunization should be strengthened.There is no need to adjust existing immune strategies.

关 键 词：麻疹 抗体水平 监测 IGG抗体 阳性率 

分 类 号：R211[医药卫生—中医学] R511.1