Two unique C21-diterpenoid alkaloids from Aconitum carmichaelii  

作　　者：Jingfang Zhang Xiaoqiang Lei Yazi Wei Hui Liu Qinglan Guo Tiantai Zhang Jiangong Shi 

机构地区：[1]State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China

出　　处：《Chinese Chemical Letters》2022年第12期5047-5050,共4页中国化学快报（英文版）

基　　金：support from the National Natural Sciences Foundation of China (Nos. 81630094 and 21732008);CAMS Innovation Fund for Medical Science (No. 2021-I2M-1-028)

摘　　要：Two sulfonated diterpenoid alkaloids possessing different but related novel carbon skeletons,named aconidenusulfonine A(1)and 12,16-secoaconidenusulfonine A(2),respectively,were isolated as minor components from an aqueous extract of the lateral roots of Aconitum carmichaelii("Fu Zi").The structures of 1 and 2,representing the first two C21-diterpenoid alkaloids from nature,were determined by analysis of various spectroscopic data and chemical transformation,of which 1 was further proved by single-crystal X-ray diffraction.Especially,1 exhibited dose-depended analgesic activity consistent with the clinical function of Fu Zi.

关 键 词：RANUNCULACEAE Aconitum carmichaelii C21-diterpenoid alkaloid Aconidenusulfonine Analgesic activity 

分 类 号：TQ460.1[化学工程—制药化工]