Dual microenvironmental parameter-responsive lysosome-targeting carbon dots for the high contrast discrimination of a broad spectrum of cancer cells  

作　　者：Yue Xiao Xiaohui Yin Pengjuan Sun Yuanqiang Sun Lingbo Qu Zhaohui Li 

机构地区：[1]College of Chemistry,Institute of Analytical Chemistry for Life Science,Henan Joint International Research Laboratory of Green Construction of Functional Molecules and Their Bioanalytical Applications,Zhengzhou University,Zhengzhou 450001,China

出　　处：《Chinese Chemical Letters》2022年第12期5051-5055,共5页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.21974125,21708035);Program for Innovative Research Team(in Science and Technology)in University of Henan Province(No.22TRTSTHN002);the 111 Project of Henan Province(No.CXJD2021001);National 111 Project(No.D20003).

摘　　要：The development of new carbon dots(CDs)for fluorescence-based cancer diagnosis has recently attracted extensive attention.Diagnosis methods based on ligand-receptor fluorescence suffer from the heterogeneity of receptor expression.Changes in the microenvironments of cancer cells provide opportunities for accurate and broad-spectrum cancer diagnosis.The lysosomes in cancer cells have lower polarity and higher viscosity than normal cells.Based on these two key microenvironmental parameters,dual-responsive CDs with inherent lysosome-targeting ability were synthesized via one-step hydrothermal treatment.The CDs exhibit many advantageous properties including facile synthesis,good water solubility,pH-independent emission,excellent photostability,good biocompatibility,and wash-free imaging ability.The CDs were successfully employed in the fluorescence-based discrimination of a broad spectrum of cancer cells from normal cells with high contrast.The CDs are promising candidates for use in the field of cancer diagnosis.

关 键 词：Carbon dots Multiple microenvironmental parameters Lysosome-targeting High contrast imaging Cancer diagnosis 

分 类 号：Q73-3[生物学—分子生物学] O657.3[理学—分析化学]