Diastereodivergent[4+2]annulation of biphenylenes with enones via nickel(0)-catalyzed C-C bond activation  

作　　者：Junyan Chen Dachang Bai Xiuli Guo Yiyao Wang Xingwei Li 

机构地区：[1]NMPA Key Laboratory for Research and Evaluation of Innovative Drug,Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals,Key Laboratory of Green Chemical Media and Reactions,Ministry of Education,School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang 453007,China [2]State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China [3]School of Chemistry and Chemical Engineering,Shaanxi Normal University(SNNU),Xi'an 710062,China

出　　处：《Chinese Chemical Letters》2022年第12期5056-5060,共5页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China (Nos. 21801067, U1804283, 21801066);the Central Plains Scholars and Scientists Studio Fund (No. 2018002);the Project funded by the Natural Science Foundation of Henan (Nos. 202300410225, 212300410181, 222102310562 and 201901023);China Postdoctoral Science Foundation (Nos. 2020T130176 and 2020M682306);financial support from Henan Key Laboratory of Organic Functional Molecules and Drug Innovation

摘　　要：Ni(0)-catalyzed regio-and diastereodivergent[4+2]annulation of biphenylenes withα,βunsaturated ketones is described.This solvent-controlled diastereodivergent reaction integrates C-C bond cleavage of biphenylene and C=C double bond insertion selectivity,offering a mild approach to all possible diastereoisomers of 9,10-dihydrophenanthrene derivatives from the same starting materials.

关 键 词：NICKEL ENONES Biphenylenes Diastereodivergent annulation C-C activation 9 10-Dihydrophenanthrenes 

分 类 号：O625.155[理学—有机化学]