伴高血压的肥厚性心肌病患者临床特征分析  

Clinical Characteristics of Hypertrophic Cardiomyopathy with Hypertension

作　　者：邓婷智[1] 欧柏青[1] 朱天刚[2] 梁力晖[1] DENG Ting-zhi;OU Bai-qing;ZHU Tian-gang(Department of Geriatric Medicine,Hunan Provincial People's Hospital,The First Affiliated Hospital of Hunan Normal University,Changsha Hunan 410006)

机构地区：[1]湖南省人民医院(湖南师范大学附属第一医院)老年病科,湖南长沙410006 [2]北京大学人民医院心脏中心,北京100029

出　　处：《医学临床研究》2022年第11期1637-1639,1643,共4页Journal of Clinical Research

基　　金：2022年湖南省卫生健康委科研课题(202203013427)。

摘　　要：【目的】比较肥厚性心肌病(HCM)合并高血压(HTN)患者与HCM未合并HTN患者临床特征。【方法】回顾性分析2012年12月至2015年7月北京大学人民医院收治的170例HCM患者的临床资料,根据是否合并HTN将其分为HCM合并HTN组(n=57)和HCM未合并HTN组(n=113)。比较两组患者基本资料、超声参数及用药情况。【结果】HCM合并HTN组患者的年龄及吸烟史、糖尿病、血脂异常、冠心病、房颤所占比例均高于对照组,差异有统计学意义(P<0.05)。超声心动图检查显示,HCM合并HTN组升主动脉内径、A峰流速明显大于HCM未合并HTN组,差异有统计学意义(P<0.05)。HCM合并HTN组血管紧张素Ⅰ转化酶抑制剂(ACEI)/血管紧张素Ⅱ受体阻滞剂(ARB)、β受体阻滞剂、利尿剂、钙离子拮抗剂、阿司匹林/氯吡格雷、他汀类、硝酸酯类的药物使用率明显高于HCM未合并HTN组(P<0.05)。【结论】HCM和HTN两者疾病可同时共患,伴HTN的HCM患者患糖尿病、高脂血症、冠心病、心房颤动的风险明显增高。【Objective】To compare the clinical characteristics of hypertrophic cardiomyopathy(HCM)with hypertension(HTN)and HCM without HTN.【Methods】The clinical data of 170 patients with HCM admitted to the People's Hospital of Peking University from December 2012 to July 2015 were analyzed retrospectively.They were divided into HCM with HTN group(n=57)and HCM without HTN group(n=113)according to whether HTN was incorporated or not.The basic data,ultrasonic parameters and medication of the two groups were compared.【Results】The age,smoking history,diabetes,dyslipidemia,coronary heart disease and atrial fibrillation of HCM patients with HTN were significantly higher than those of the control group(P<0.05).Echocardiography showed that the diameter of ascending aorta in HCM with HTN group was significantly wider than that in HCM without HTN group(P<0.05).The drug use rates of HCM combined with HTN group ACEI/ARB,βreceptor blockers,diuretics,calcium antagonists,aspirin/clopidogrel,statins and nitrates were significantly higher than those of HCM without HTN(P<0.05).【Conclusion】HCM and HTN can coexist at the same time.HCM patients with HTN have a significantly higher risk of diabetes,hyperlipidemia,coronary heart disease,and atrial fibrillation.

关 键 词：心肌病 肥厚性/并发症 高血压/并发症 

分 类 号：R542.2[医药卫生—心血管疾病]