清热凉血汤联合NB-UVB治疗血虚风热型白癜风患者的临床疗效  

Clinical Study of Qingre Liangxue Decoction Combined with NB-UVB in Treating Vitiligo with Blood Deficiency and Wind-heat Type

作　　者：张霞 雷雅丽 ZHANG Xia;LEI Ya-li(Department of Dermatology,Yangling Demonstration Area Hospital,Yangling Shaanxi 712100)

机构地区：[1]杨凌示范区医院皮肤科,陕西杨凌712100 [2]宝鸡市解放军联勤保障部队第九八七医院皮肤科,陕西宝鸡721004

出　　处：《医学临床研究》2022年第11期1698-1701,共4页Journal of Clinical Research

摘　　要：【目的】探讨清热凉血汤联合窄谱中波紫外线(NB-UVB)治疗血虚风热型白癜风患者的临床价值。【方法】选取2017年1月至2021年9月在杨凌示范区医院皮肤科门诊就诊的90例白癜风患者,按随机数字表法分为观察组和对照组,两组45例。对照组患者采用NB-UVB治疗,观察组患者在对照组基础上加服清热凉血汤,两组均治疗6周。比较两组患者临床疗效、治疗期间不良反应及治疗前后中医证候积分、CXC趋化因子配体16(CXCL16)、转化生长因子-β1(TGF-β1)、白介素-26(IL-26)、T淋巴细胞(CD4^(+)、CD8^(+)及CD4^(+)/CD8^(+))。【结果】观察组总有效率为93.33%,显著高于对照组的77.78%(P<0.05);两组治疗后局部白斑、面色淡白、食欲不振、头晕眼花、心悸失眠、乏力评分显著低于治疗前(P<0.05),且观察组治疗后上述症状评分显著低于对照组(P<0.05);两组治疗后CXCL16、TGF-β1、IL-26水平显著低于治疗前(P<0.05),且观察组治疗后CXCL16、TGF-β1、IL-26水平显著低于对照组(P<0.05);两组治疗后CD4^(+)、CD4^(+)/CD8^(+)显著高于治疗前,CD8^(+)显著低于治疗前(P<0.05),且观察组治疗后CD4^(+)、CD4^(+)/CD8^(+)显著高于对照组,CD8^(+)显著低于对照组(P<0.05);两组治疗期间不良反应总发生率比较,差异无统计学意义(P>0.05)。【结论】清热凉血汤联合NB-UVB治疗血虚风热型白癜风疗效好,可有效缓解患者的临床症状,抑制炎症反应,调节免疫功能,且安全性好,值得临床推广应用。【Objective】To explore the clinical value of Qingre Liangxue Decoction combined with narrow-band ultraviolet(NB-UVB)in the treatment of vitiligo showing blood deficiency and wind-heat type.【Methods】A total of 90 patients with vitiligo who visited Yangling Demonstration Area Hospital dermatology clinic from January 2017 to September 2021 were selected as the study subjects.Patients were divided into the observation group and the control group according to the random number table method,with 45 cases in each group.Patients in the control group were treated with NB-UVB,and patients in the observation group were treated with Qingre liangxue Decoction on the basis of the control group.The treatment period of both groups was 6 weeks.The treatment effects and adverse reactions during the treatment were compared between the two groups of patients.The scores of TCM syndromes,CXC chemokine ligand 16(CXCL16),transforming growth factor-β1(TGF-β1),Interleukin-26(IL-26)and T lymphocytes(CD4^(+),CD8^(+)and CD4^(+)/CD8^(+))were compared between the two groups before and after treatment.【Results】The total effective rate of the observation group was 93.33%,which was significantly higher than that of the control group 77.78%(P<0.05).The scores of local leukoplakia,pale complexion,loss of appetite,dizziness,palpitations,insomnia,and fatigue after treatment in the two groups were significantly lower than those before treatment(P<0.05).After treatment,the observation group's local leukoplakia,pale complexion,loss of appetite,dizziness,palpitations,insomnia,and fatigue scores were significantly lower than those of the control group(P<0.05).The levels of CXCL16,TGF-β1 and IL-26 after treatment in the two groups were significantly lower than those before treatment(P<0.05).After treatment,levels of CXCL16,TGF-β1,and IL-26 in the observation group were significantly lower than those in the control group(P<0.05).CD4^(+),CD4^(+)/CD8^(+)after treatment in the two groups were significantly higher than those before treatment,whil

关 键 词：白癜风/治疗 紫外线疗法 治疗结果 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]