左心室心肌功能参数评估2型糖尿病患者血清补体C3水平  

Left ventricular myocardial function parameters for diagnosis of serum complement C3 level in patients with type 2 diabetes mellitus

作　　者：张梦娇 沙蕾 曹萌萌 童揽月 沈崔琴 杜联芳[3] 李朝军 ZHANG Mengjiao;SHA Lei;CAO Mengmeng;TONG Lanyue;SHEN Cuiqin;DU Lianfang;LI Zhaojun(Department of Medical Imaging,Weifang Medical University,Weifang 261053,China;Department of Ultrasound,Jiading Branch of Shanghai General Hospital,Shanghai 201803,China;Department of Ultrasound,Shanghai General Hospital,Shanghai Jiaotong University,Shanghai 200080,China)

机构地区：[1]潍坊医学院医学影像学院,山东潍坊261053 [2]上海市第一人民医院嘉定分院超声科,上海201803 [3]上海交通大学医学院附属第一人民医院超声科,上海200080

出　　处：《中国医学影像技术》2022年第12期1817-1822,共6页Chinese Journal of Medical Imaging Technology

基　　金：上海市科技计划项目(21ZR1451400);上海市嘉定区卫生健康委员会科研课题计划(2021-KY-10);上海市嘉定区江桥医院“科技计划”(202127A);上海市卫生健康委员会卫生行业临床研究专项(202240235)。

摘　　要：目的观察左心室心肌功能参数评估2型糖尿病(T2DM)患者血清补体C3水平的价值。方法纳入38例T2DM患者,按C3水平将其分为低C3(C3^(-)组,n=19)和高C3组(C3^(+)组,n=19),另以61例无糖尿病及心脑血管病史的甲状腺结节或乳腺结节患者为对照组;比较3组实验室指标、舒张末期室间隔厚度(IVSD)、舒张末期左心室后壁厚度(LVPWD)、舒张末期左心室内径(LVEDD)、收缩末期左心室内径(LVESD)、左心室射血分数(LVEF)、左心室心内膜下心肌整体圆周应变(GCS_(endo))、中层心肌整体圆周应变(GCS_(mid))及心外膜下心肌整体圆周应变(GCS_(epi)),分析GCS_(endo)、GCS_(mid)、GCS_(epi)与实验室指标的相关性,观察以之评估患者血清补体C3水平的价值。结果空腹血糖、糖化血红蛋白、单核细胞、中性粒细胞百分比、淋巴细胞百分比、嗜酸性粒细胞百分比、嗜碱性粒细胞百分比、补体C3水平、LVESD、IVSD、E/e、e/a、GCS_(endo)、GCS_(mid)及GCS_(epi)3组总体差异均有统计学意义(P均<0.05)。GCS_(endo)、GCS_(mid)及GCS_(epi)均与空腹血糖(r=0.198、0.185、0.214,P均<0.05)和糖化血红蛋白(r=0.236、0.202、0.249,P均<0.05)呈正相关,与中性粒细胞百分比呈负相关(r=-0.162、-0.162、-0.165,P均<0.05);控制空腹血糖后偏相关分析结果显示,GCS_(endo)、GCS_(mid)及GCS_(epi)均与糖化血红蛋白和中性粒细胞百分比无明显相关(P均>0.05)。以GCS_(endo)、GCS_(mid)和GCS_(epi)评估T2DM患者血清补体C3水平的曲线下面积(AUC)分别为0.754、0.710和0.707,GCS_(endo)的AUC高于GCS_(mid)和GCS_(epi)(P均<0.05)。结论GCS_(endo)可用于评估T2DM患者血清补体C3水平。Objective To explore the value of left ventricular myocardial function parameters for evaluating serum complement C3 level in patients with type 2 diabetes mellitus(T2DM).Methods Thirty-eight T2DM patients were enrolled and divided into low(C3^(-)group,n=19)and high C3 group(C3^(+)group,n=19)according to C3 level,and 61 patients with thyroid nodules or breast nodules without history of diabetes,cardiovascular nor cerebrovascular diseases were taken as controls(control group).The laboratory indexes,interventricular septal thickness at diastole(IVSD),left ventricular posterior wall diameter at diastole(LVPWD),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),left ventricular ejection fraction(LVEF),endocardial myocardial global circumferential strain(GCS_(endo)),mid-myocardial global circumferential strain(GCS_(mid))and epicardial myocardial global circumferential strain(GCS_(epi))were compared among 3 groups.The correlations of GCS_(endo),GCS_(mid),GCS_(epi)and laboratory indexes were observed,and their values for evaluating serum complement C3 level were analyzed.Results There were significant differences of fasting blood glucose,glycosylated hemoglobin,monocyte,neutrophil percentage,lymphocyte percentage,eosinophil percentage,basophil percentage,complement C3 level,LVESD,IVSD,E/e,e/a,GCS_(endo),GCS_(mid)and GCS_(epi)among 3 groups(all P<0.05).GCS_(endo),GCS_(mid)and GCS_(epi)were positively correlated with fasting blood glucose(r=0.198,0.185,0.214,all P<0.05)and glycosylated hemoglobin(r=0.236,0.202,0.249,all P<0.05),but negatively correlated with neutrophil percentage(r=-0.162,-0.162,-0.165,all P<0.05).Partial correlation analysis of fasting blood glucose control showed that GCS_(endo),GCS_(mid)and GCS_(epi)were not significantly correlated with glycosylated hemoglobin and neutrophil percentage(all P>0.05).The area under the curve(AUC)of GCS_(endo),GCS_(mid)and GCS_(epi)for evaluating complement C3 level in T2DM patients was 0.754,0.710 and 0.707,respectively,and the A

关 键 词：糖尿病 2型 补体C3 心室功能 左 超声检查 

分 类 号：R587.1[医药卫生—内分泌] R445.1[医药卫生—内科学]