微小RNA调控胶质瘤化学治疗耐药的研究进展  

Research Progress of MicroRNA for Regulating Chemotherapy Resistance in Glioma

作　　者：曾昭穆 李琳 郭岩松 祁惠秀 刘永 闫晴宇 郑克彬[1] ZENG Zhaomu;LI Lin;GUO Yansong;QI Huixiu;LIU Yong;YAN Qingyu;ZHENG Kebin(Department of Neurosurgery,the Affiliated Hospital of Hebei University,Baoding 071000,China;School of Clinical Medicine,Hebei University,Baoding 071000,China)

机构地区：[1]河北大学附属医院神经外科,保定071000 [2]河北大学临床医学院,保定071000

出　　处：《医药导报》2023年第1期78-85,共8页Herald of Medicine

基　　金：2022年河北省研究生创新资助项目(CXZZBS2022015);2019年政府资助临床医学优秀人才培养项目(团队)(361007)。

摘　　要：神经胶质瘤是脑部肿瘤相关性死亡的主要原因之一。尽管手术联合放射治疗(放疗)和化学治疗(化疗)方案可以显著提高患者的生活质量,但由于耐药性,胶质瘤的高病死率和复发率仍然导致患者总体生存率低。微小RNA(miRNA)作为肿瘤表观遗传的关键调节因子,与胶质瘤耐药性之间有着彼此交错的互作网络。这些耐药调控网络极为复杂,目前尚未完全阐明。该文系统总结了miRNA在多种抗肿瘤药(替莫唑胺、顺铂、植物源性抗肿瘤药、分子靶向药和免疫治疗药)耐药中的作用和分子机制,并重点讨论miRNA作为胶质瘤耐药治疗靶点的潜在功能,以及使用纳米材料作为miRNA载体治疗胶质瘤的潜在价值,为逆转胶质瘤耐药和纳米医学在临床诊治中的研究提供参考。Neuroglioma is the main relative death reason for brain tumors.Although the scheme of operation with chemoradiotherapy can significantly improve the survival quality of the patients,the high death rate and recurrence rate of glioma lead to the general low survival rate of the patients on account of drug resistance.It is well known that,as the inherited key regulatory factor of tumor surface appearance,microRNA(miRNA)has a network of interlaced interactional influence with the drug resistance of glioma proved by a large amount of research.The pity is that these regulatory networks of drug resistance are extremely complicated,which has not been illustrated completely.Therefore,this paper summarizes the effects and molecular mechanism of miRNA in the drug resistance of various anti-tumor medicines(temozolomide,cisplatinum,antitumor agents of plant origin,molecular targeting drug,and immunotherapy agent),and mainly discusses the potential function of miRNA as the glioma drug therapeutic target,and the potential value of using nanometer materials as the carrier of miRNA to treat glioma.It will provide references for the study of reversal of glioma drug resistance and nano-medicine in clinical diagnosis and treatment.

关 键 词：微小RNA 胶质瘤 化学治疗 耐药 纳米载体 

分 类 号：R979.1[医药卫生—药品] R730.264[医药卫生—药学]