盐酸氨溴索联合头孢哌酮钠他唑巴坦钠治疗老年CAP的疗效及对血清PCT、TNF-α、hs-CRP、ESR影响  

Efficacy of ambroxol hydrochloride combined with cefoperazone sodium and tazobactam sodium in the treatment of elderly CAP and its effect on serum PCT,TNF-α,hs-CRP and ESR

作　　者：陈兰芳 梁婉如 余海鹏 Chen Lan-fang;Liang Wan-ru;Yu Hai-peng(Department of Internal Medicine,Hengli Hospital,Dongguan 523460,Guangdong,China)

机构地区：[1]东莞市横沥医院内二科,广东东莞523460

出　　处：《医学食疗与健康》2022年第26期27-29,51,共4页Medical Diet and Health

摘　　要：目的:探究盐酸氨溴索联合头孢哌酮钠他唑巴坦钠治疗老年社区获得性肺炎(CAP)的疗效及对血清降钙素(PCT)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、红细胞沉降率(ESR)影响。方法:选取2018年2月至2020年12月本院接收的52例老年CAP患者作为此次研究对象,并采用随机数字表法将其分为常规组和研究组,各26例。常规组采用盐酸氨溴索+左氧氟沙星治疗,而研究组采用盐酸氨溴索+头孢哌酮钠他唑巴坦钠治疗,比较两组的临床疗效、治疗前后的血清PCT、TNF-α、hs-CRP、ESR变化情况。结果:治疗后,研究组的临床总有效率(96.15%)高于常规组(76.92%)(P<0.05);同时,研究组的血清PCT、TNF-α、hs-CRP、ESR均低于常规组(P<0.05)。结论:在老年CAP患者中采用盐酸氨溴索联合头孢哌酮钠他唑巴坦钠治疗,能进一步提高临床疗效,并降低患者的血清PCT、TNF-α、hs-CRP、ESR水平。Objective:To explore the efficacy of ambroxol hydrochloride combined with cefoperazone sodium and tazobactam sodium in the treatment of elderly community-acquired pneumonia(CAP)and the treatment of serum calcitonin(PCT),tumor necrosis factor-α(TNF-α),and high sensitivity C-reactive protein(hs-CRP),erythrocyte sedimentation rate(ESR).Methods:Fifty-two elderly CAP patients received in our hospital from February 2018 to December 2020 were selected as the research objects,and they were divided into a routine group and a study group using a random number table method,with 26 cases in each group.The routine group was treated with ambroxol hydrochloride+levofloxacin,while the study group was treated with ambroxol hydrochloride+cefoperazone sodium and tazobactam sodium.The clinical efficacy,serum PCT,TNF-α,hs-CRP,ESR before and after treatment were compared between the two groups Changes.Results:After treatment,the total clinical effective rate(96.15%)of the study group was higher than that of the conventional group(76.92%)(P<0.05);at the same time,the serum PCT,TNF-α,hs-CRP,and ESR of the study group were lower than those of the conventional group(P<0.05).Conclusion:The treatment of ambroxol hydrochloride combined with cefoperazone sodium and tazobactam sodium in elderly CAP patients can further improve the clinical efficacy and reduce the patients'serum PCT,TNF-α,hs-CRP,and ESR levels.

关 键 词：老年CAP 盐酸氨溴索 头孢哌酮钠他唑巴坦钠 PCT TNF-Α HS-CRP ESR 

分 类 号：R563.1[医药卫生—呼吸系统]