不典型川崎病患儿Th17细胞因子水平与冠状动脉病变的关系  

The Relationship Between Th17 Cytokine Levels and Coronary Artery Lesions in Children with Atypical Kawasaki Disease

作　　者：郭东梅[1] 张文华[1] 周锦云[1] GUO Dong-mei;ZHANG Wen-hua;ZHOU Jin-yun(Department of Pediatrics,Tianjin Fourth Central Hospital,Tianjin 300143,China)

机构地区：[1]天津市第四中心医院儿科,天津300143

出　　处：《医学信息》2022年第22期92-95,共4页Journal of Medical Information

摘　　要：目的分析不典型川崎病患儿Th17细胞因子水平与冠状动脉病变的关系。方法选取2019年1月-2021年12月天津市第四中心医院门诊及住院收治的不典型川崎病患儿102例作为疾病组,另选取同期接收的98例健康体检儿童作为对照组,记录两组血清白细胞(WBC)、血小板计数(PLT)、红细胞沉降率(ESR)、C反应蛋白(CRP)、白介素-17A(IL-17A)水平,比较两组血清IL-17A水平。采用Logistic多元回归分析探讨血清IL-17A水平与疾病组冠状动脉病变的关系。结果疾病组血清IL-17A水平为(14.89±2.45)ng/L,高于对照组的(4.52±0.58)ng/L,差异有统计学意义(P<0.05);疾病组冠状动脉病变发生率为25.49%,冠状动脉病变发生者WBC、PLT、ESR、CRP水平、IL-17A水平均高于未发生冠状动脉病变者,差异有统计学意义(P<0.05);WBC、PLT、ESR、CRP、IL-17A水平均是疾病组冠状动脉病变的影响因素(OR=2.415、2.782、2.816、3.649、4.493,P<0.05)。结论不典型川崎病患儿Th17细胞因子IL-17A水平升高,且WBC、PLT、ESR、CRP均是冠状动脉病变发生的影响因素。Objective To analyze the relationship between Th17 cytokine levels and coronary artery lesions in children with atypical Kawasaki disease.Methods A total of 102 children with atypical Kawasaki disease admitted to the outpatient and inpatient departments of Tianjin Fourth Central Hospital from January 2019 to December 2021 were selected as the disease group,and 98 healthy children received physical examination during the same period were selected as the control group.The levels of serum white blood cell(WBC),platelet count(PLT),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),and interleukin-17A(IL-17A)were recorded in the two groups,and the levels of serum IL-17A were compared between the two groups.Logistic multiple regression analysis was used to explore the relationship between serum IL-17A level and coronary artery disease in the disease group.Results The serum IL-17 A level in the disease group was(14.89±2.45)ng/L,which was higher than(4.52±0.58)ng/L in the control group,and the difference was statistically significant(P<0.05).The incidence of coronary artery disease in the coronary artery disease group was 25.49%.The levels of WBC,PLT,ESR,CRP and IL-17 A in patients with coronary artery disease were higher than those without coronary artery disease,and the differences were statistically significant(P<0.05).The levels of WBC,PLT,ESR,CRP and IL-17 A were the influencing factors of coronary artery disease in the disease group(OR=2.415,2.782,2.816,3.649,4.493,P<0.05).Conclusion The level of Th17 cytokine IL-17A is increased in children with atypical Kawasaki disease,and WBC,PLT,ESR and CRP are the influencing factors of coronary artery disease.

关 键 词：不典型川崎病 辅助性T细胞17 白介素-17A 冠状动脉病变 

分 类 号：R725.9[医药卫生—儿科]