绝经后骨质疏松症相关长链非编码RNA的研究进展  

Research Progress of Long-Non-coding RNA Related to Postmenopausal Osteoporosis

作　　者：陈明昊 青玉凤[2] 苟婉星 李素平[1] CHEN Ming-hao;QING Yu-feng;GOU Wan-xing;LI Su-ping(Department of Nuclear Medicine,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan,China;Department of Rheumatism and Immunology,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan,China)

机构地区：[1]川北医学院附属医院核医学科,四川南充637000 [2]川北医学院附属医院风湿免疫科,四川南充637000

出　　处：《医学信息》2022年第22期160-164,共5页Journal of Medical Information

基　　金：国家自然科学基金面上项目(编号:81974250)。

摘　　要：绝经后骨质疏松症(PMOP)是绝经后妇女常见的全身性、代谢性骨病,以骨量降低和骨组织微结构破坏、退化为特征,增加了绝经后妇女骨折的风险。现有研究显示长链非编码RNA(lncRNA)在调节成骨细胞分化、破骨细胞分化等方面有重要作用。本文就lncRNA在PMOP中调控骨代谢的作用、与微小RNA(miRNA)及雌激素的相互作用等方面展开综述,以期为临床PMOP的诊治提供一定参考。Postmenopausal osteoporosis(PMOP)is a common systemic and metabolic bone disease in postmenopausal women.It is characterized by decreased bone mass and destruction and degradation of bone microstructure,which increases the risk of fracture in postmenopausal women.Existing studies have shown that long non-coding RNA(lncRNA)plays an important role in regulating osteoblast differentiation and osteoclast differentiation.This article reviews the role of lncRNA in regulating bone metabolism in PMOP and its interaction with microRNA(miRNA)and estrogen,in order to provide some reference for the diagnosis and treatment of clinical PMOP.

关 键 词：绝经后骨质疏松症 长链非编码RNA 雌激素 微小RNA 

分 类 号：R681[医药卫生—骨科学]