细胞焦亡与支气管哮喘关系的研究  

Study on the Relationship Between Pyroptosis and Bronchial Asthma

作　　者：姜晓红[1] 黄玉钾 谷梦霞 JIANG Xiao-hong;HUANG Yu-jia;GU Meng-xia(Department of Geriatric Respiratory Medicine,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,Guangxi,China)

机构地区：[1]广西医科大学第一附属医院老年呼吸内科,广西南宁530021

出　　处：《医学信息》2022年第22期165-169,共5页Journal of Medical Information

摘　　要：细胞焦亡(pyroptosis)是近年来新发现的一种与炎症相关的细胞程序性死亡形式,与细胞凋亡不同,它常伴随着细胞的胀破、胞内促炎物质的外泄,进而引发严重的炎症反应。支气管哮喘是一种以多种细胞、细胞组分参与的气道慢性炎症性疾病,目前关于其机制尚不明确。近年来越来越多的证据表明细胞焦亡与支气管哮喘密切相关。基于此,本文就细胞焦亡与支气管哮喘的关系作一综述。Pyroptosis is a newly discovered form of programmed cell death associated with inflammation in recent years.Unlike apoptosis,pyroptosis is often accompanied by cell bursting and the leakage of intracellular pro-inflammatory substances,which in turn triggers a serious inflammatory response.Bronchial asthma is a chronic airway inflammatory disease involving multiple cells and cellular components.At present,the mechanism is not clear.In recent years,more and more evidence suggests that pyroptosis is closely related to bronchial asthma.Based on this,this article reviews the relationship between pyroptosis and bronchial asthma.

关 键 词：细胞焦亡 支气管哮喘 炎性小体 信号通路 

分 类 号：R562.25[医药卫生—呼吸系统] G353.11[医药卫生—内科学]