毓麟珠联合地诺孕素治疗卵巢子宫内膜异位囊肿疗效及对患者卵巢功能的影响  

Clinicalefficacy of Yulinzhu combined with dienogest in the treatment of ovarian endometrioma and its effect on ovarian function

作　　者：陈赟[1] 周雨欣 王伟[1] 李健美[1] 卢苏[1] CHEN Yun;ZHOU Yuxin;WANG Wei;LI Jianmei;LU Su(Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China)

机构地区：[1]南京中医药大学附属医院,江苏南京210029 [2]南京中医药大学,江苏南京210029

出　　处：《陕西中医》2023年第1期29-32,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金青年基金资助项目(81904236);江苏省妇幼健康青年人才项目(FRC202150)。

摘　　要：目的:探究毓麟珠联合地诺孕素治疗卵巢子宫内膜异位囊肿临床疗效及对患者卵巢功能的影响。方法:选取60例卵巢子宫内膜异位囊肿患者,按随机法分成对照组(n=30)和试验组(n=30),两组均给予地诺孕素片治疗,在此基础上,给予试验组患者毓麟珠联合治疗6个月,比较两组患者的临床疗效、肿瘤标记物、停药后的卵泡发育、1年后妊娠率、不良反应情况。结果:试验组患者的临床治疗总有效率明显高于对照组(P<0.05);治疗前,两组患者的肿瘤糖类抗原125(CA125)及糖类抗原199(CA199)指标比较差异均无统计学意义(P>0.05);用药6个月,试验组妇科肿瘤指标CA125低于对照组(P<0.05),两组CA199比较差异无统计学意义(P>0.05);停药时,两组患者的卵泡发育比例比较差异无统计学意义(P>0.05);停药3个月备孕期,两组患者的卵泡发育占比均提升,且试验组高于对照组(P<0.05);1年后,试验组患者的妊娠率高于对照组(P<0.05),而不良反应发生率低于对照组(P<0.05)。结论:给予卵巢子宫内膜异位囊肿患者毓麟珠联合地诺孕素治疗可有效增强患者临床疗效,改善其卵巢功能,提高生育能力具有重要作用,并降低不良反应。Objective:To investigate the clinical efficacy of Yulinzhu combined with dienogest in the treatment of ovarian endometriosis cyst and its influence on ovarian function.Methods:60 patients with ovarian endometriosis cyst were randomly divided into the control group(n=30)and the test group(n=30)according to the sorting method.Both groups were treated with dienogest tablets.On this basis,the patients in the test group were treated with Yulinzhu combination therapy.The clinical efficacy,tumor markers,follicular development after drug withdrawl,pregnancy rate after one year,and adverse reactions of the two groups were compared.Results:The effective rate of clinical treatment in the test group was significantly higher than that in the control group(P<0.05);Before treatment,the indexes of tumor carbohydrate antigen 125(CA125)and carbohydrate antigen 199(CA199)in the two groups had no significant difference(P>0.05).After 6 months of treatment,the gynecological tumor index CA125 in the treatment group was lower than that in the control group(P<0.05),and the difference of CA199 was not statistically significant(P>0.05);When the treatment was stopped,there was no significant difference between the two groups in the proportion of follicular development(P>0.05).The proportion of follicular development in the two groups increased after the treatment was stopped for 3 months in preparation for pregnancy,and the test group was higher than the control group(P<0.05).One year later,the pregnancy rate in the test group was higher than that in the control group(P<0.05),while the incidence of adverse reactions was lower than that in the control group(P<0.05).Conclusion:The combination of Yulinzhu and dienogest can effectively enhance the clinical efficacy of patients with ovarian endometriosis cyst,improve their ovarian function,reduce adverse reactions improve fertility.

关 键 词：卵巢子宫内膜异位囊肿 毓麟珠 地诺孕素 卵巢功能 糖类抗原125 糖类抗原199 

分 类 号：R711.74[医药卫生—妇产科学]