补肾疏肝安神法治疗更年期失眠症疗效研究  

Clinical efficacy of tonifying kidney,soothing liver and tranquilizing spirit in treatment of perimenopausal insomnia

作　　者：许文杰[1] 周一心[1] 蒋瑞冲 王琦伟 秦勇[1] XU Wenjie;ZHOU Yixin;JIANG Ruichong;WANG Qiwei;QIN Yong(Shanghai Seventh People’s Hospital,Shanghai 200137,China)

机构地区：[1]上海市第七人民医院,上海200137

出　　处：《陕西中医》2023年第1期41-44,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：上海市浦东新区名中医人才建设项目(PWRZM2020-08);上海市第七人民医院名中医继承人项目(JCR2020-01)。

摘　　要：目的:观察补肾疏肝安神法对更年期失眠患者的睡眠质量及对患者E_(2)、LH、FSH的影响。方法:将100例更年期失眠患者随机分为研究组(n=50)和对照组(n=50),两组患者均给予睡眠健康宣教和相关心理疏导治疗下,对照组给予艾司唑仑治疗,研究组给予补肾疏肝安神法中药治疗,疗程均为12周。比较两组患者的临床疗效、匹兹堡睡眠质量指数量表(PSQI)评分、SPIEGEL量表评分及血清雌二醇(E_(2))、促黄体激素(LH)、促卵泡激素(FSH)水平变化。结果:治疗后,治疗组的临床疗效优于对照组(P<0.05)。研究组PSQI评分优于对照组(P<0.05),研究组SPIEGEL评分优于对照组(P<0.05)。治疗后,两组血清E_(2)水平均明显升高,LH、FSH水平明显降低,且研究组的改善幅度较对照组更为明显(P<0.05)。结论:补肾疏肝安神法治疗更年期失眠症患者临床效果显著,可改善患者睡眠质量。Objective:To explore the effect of tonifying kidney,soothing liver and tranquilizing spirit on sleep quality and E_(2),LH,FSH of permenopausal insomnia patients.Methods:100 permenopausal patients with insomnia were randomly divided into study group(n=50)and control group(n=50).Two groups of patients were given sleep health education and related psychological counseling therapy.The control group was given estazolam,and the study group was given the treatment of tonifying kidney,soothing liver and tranquilizing spirit decoction.The treatment course was 12 weeks.Clinical efficacy,Pittsburgh Sleep Quality Index(PSQI)score and SPIEGEL scale score and levels of serum estradiol(E_(2)),follicle-stimulating hormone(FSH)and luteinizing hormone(LH)were compared between 2 groups.Results:After treatment,the clinical efficacy of the treatment group was better than that in the control group(P<0.05).PSQI score of treatment group was better than that in control group(P<0.05),SPIEGEL score of treatment group was better than control group(P<0.05).After treatment,serum E_(2) level in both groups were significantly increased,while LH and FSH levels were significantly decreased,and the improvement in the study group was more obvious than that in the control group(P<0.05).Conclusion:The clinical effect of tonifying kidney,soothing liver and tranquilizing spirit in treating patients with perimenopausal insomnia is remarkable,which can improve the sleep quality of patients.

关 键 词：更年期 失眠症 睡眠质量 补肾疏肝安神法 雌二醇 促黄体激素 促卵泡激素 

分 类 号：R271.116[医药卫生—中医妇科学]