复方丹参滴丸联合阿托伐他汀治疗冠心病合并心绞痛疗效及对患者氧化应激指标的影响  

Efficacy of compound Danshen dripping pills combined with atorvastatin in the treatment of coronary heart disease with angina pectoris and its influence on oxidative stress indicators of patients

作　　者：曾建勇 王小玲[2] 范小虹 魏京霞[1] ZENG Jianyong;WANG Xiaoling;FAN Xiaohong;WEI Jingxia(Department of Pharmacy,the Sixth People’s Hospital of Chengdu,Chengdu 610051,China)

机构地区：[1]成都市第六人民医院药剂科,四川成都610051 [2]四川省骨科医院药剂科,四川成都610051

出　　处：《陕西中医》2023年第1期55-59,共5页Shaanxi Journal of Traditional Chinese Medicine

基　　金：四川省医学会科研课题(2019HR36)。

摘　　要：目的:研究复方丹参滴丸联合阿托伐他汀用于冠心病合并心绞痛患者的治疗疗效及对患者氧化应激指标的影响。方法:选择114例冠心病合并心绞痛患者作为研究对象,按单双号法随机分配到联合组(n=57)和单一组(n=57),均给予常规治疗,其中单一组加以阿托伐他汀治疗,联合组加用复方丹参滴丸,比较两组患者治疗前及治疗2个月后临床疗效、心绞痛改善情况、心功能指标、血液流变学指标、血清氧化应激指标,并比较治疗期间两组患者不良心血管事件总发生率。结果:治疗2个月后,联合组总有效率为92.98%,显著高于单一组的82.46%(P<0.05);两组患者心绞痛发作频率、发作时间较治疗前显著降低(P<0.05),联合组显著低于单一组(P<0.05);治疗2个月后,两组患者左心室射血分数(LVEF)、6分钟步行距离(6MWD)均较治疗前显著提高(P<0.05),左心室收缩末内径(LVESD)、左心室舒张末期内径(LVEDD)均较治疗前显著降低(P<0.05),联合组治疗后比较差异有统计学意义(P<0.05);治疗2个月后,两组患者全血高切黏度、全血低切黏度、血浆黏度较治疗前显著降低(P<0.05),两组患者血清总超氧化物歧化酶(T-SOD)、谷胱甘肽过氧化物酶(GSH-Px)活力较治疗前显著提高(P<0.05),联合组显著高于单一组(P<0.05);丙二醛(MDA)、乳酸(LD)含量较治疗前显著降低(P<0.05),联合组显著低于单一组(P<0.05);治疗期间,联合组和单一组不良心血管事件总发生率分别为3.51%和1.76%,比较差异无统计学意义(P>0.05)。结论:复方丹参滴丸联合阿托伐他汀治疗冠心病合并心绞痛效果良好,能明显降低心绞痛的发生情况、改善患者心功能和血液流变学,同时缓解氧化应激状态,药物方案安全性良好,值得临床应用。Objective:To study the therapeutic efficacy of compound Danshen dripping pills combined with atorvastatin on patients with coronary heart disease complicated with angina pectoris and its influence on oxidative stress indicators of patients.Methods:114 patients with coronary heart disease complicated with angina pectoris were selected as the research subjects,and they were randomly assigned to combined group(n=57)and single group(n=57)according to the odd and even number method.All the patients were given conventional treatment,and single group was additionally treated with atorvastatin,and the combined group was additionally given compound Danshen dripping pills.The clinical efficacy,improvement of angina pectoris,cardiac function indicators,hemorheological indicators and serum oxidative stress indicators were compared between the two groups before treatment and after 2 months of treatment.The total incidence rate of adverse cardiovascular events of the two groups of patients was compared during treatment.Results:After 2 months of treatment,the total effective rate with 92.98%of combined group was significantly higher than 82.46%of single group(P<0.05).The frequency and duration of angina pectoris in the two groups of patients were significantly decreased compared with those before treatment(P<0.05),and the frequency and duration of combined group were significantly lower than those in single group(P<0.05).After 2 months of treatment,the left ventricular ejection fraction(LVEF)and 6-minute walking distance(6MWD)of the two groups were significantly improved compared to before treatment(P<0.05),while the left ventricular end-systolic diameter(LVESD)and left ventricular end-diastolic diameter(LVEDD)were significantly reduced compared to before treatment(P<0.05),and the indicators in combined group were significantly different from those in single group after treatment(P<0.05).After 2 months of treatment,the whole blood high-shear viscosity,whole blood low-shear viscosity and plasma viscosity of the two groups were s

关 键 词：冠心病 心绞痛 复方丹参滴丸 阿托伐他汀 氧化应激 血液流变学 

分 类 号：R541.4[医药卫生—心血管疾病]