血清抗PLA2R抗体、增殖诱导配体、24 h尿蛋白水平联合检测在特发性膜性肾病中的应用价值  

Application value of combined detection of serum anti PLA2R antibody,proliferation inducing ligand and 24-hour urinary protein in idiopathic membranous nephropathy

作　　者：李红莉[1] 贾红红 LI Hongli;JIA Honghong(Department of Nephrology,Yan’an People’s Hospital,Yan’an 716000,China)

机构地区：[1]延安市人民医院肾内科,陕西延安716000

出　　处：《陕西医学杂志》2023年第1期93-96,共4页Shaanxi Medical Journal

基　　金：陕西省延安市科技惠民计划项目(2017HM-07-04)。

摘　　要：目的:探究在特发性膜性肾病中采用血清抗PLA2R抗体、增殖诱导配体(APRIL)、24 h尿蛋白水平联合检测的应用价值。方法:研究对象为80例特发性膜性肾病患者与30例进行体检健康者。回顾80例患者的病历资料,所有患者的病情均经肾穿刺活检病理检查确诊,并按病理分期分为3组,即病理分期为1期者为观察A组(25例),病理分期为2期者为观察B组(30例),病理分期为3期者为观察C组(25例),健康体检者为对照组。四组参与研究者,均开展血清抗PLA2R抗体、增殖诱导配体(APRIL)、24 h尿蛋白水平检测,对比四组血清抗PLA2R抗体、增殖诱导配体(APRIL)、24 h尿蛋白水平,同时评估联合检测在特发性膜性肾病中的应用价值。结果:特发性膜性肾病患者的抗PLA2R抗体、APRIL、24 h尿蛋白水平明显高于对照组相应指标水平,比较差异具有统计学意义(均P<0.05);三组患者的血清抗PLA2R抗体、APRIL、24 h尿蛋白水平比较差异无统计学意义(均P>0.05),其中观察C组患者以上指标高于观察1、2组,观察B组患者以上指标高于观察A组,比较差异均具有统计学意义(均P<0.05);血清抗PLA2R抗体表达越高,患者的APRIL、24 h尿蛋白水平越高,之间存在明显的正相关关系,比较差异具有统计学意义(均P<0.05)。结论:特发性膜性肾病采用血清抗PLA2R抗体、增殖诱导配体(APRIL)、24 h尿蛋白水平联合检测,不仅可以检测出相关病情,还可以对病情的严重程度进行鉴别诊断。Objective:To explore the application value of combined detection of serum anti PLA2R antibody,proliferation inducing ligand(APRIL)and 24-hour urinary protein in idiopathic membranous nephropathy.Methods:A total of 80 patients with idiopathic membranous nephropathy and 30 healthy subjects were studied.The medical records of 80 patients were reviewed.All patients’conditions were confirmed by pathological examination of renal puncture biopsy,and were divided into three groups according to pathological stages,that was,those with pathological stage 1 were observation group 1(25 cases),and those with pathological stage 2 were observation group 2(30 cases),and those with pathological stage 3 were the observation group(25 cases),and the healthy people were the control group.For all the four groups of participants,the detection of serum anti PLA2R antibody,APRIL and 24-hour urinary protein levels were carried out.The levels of serum anti PLA2R antibody,APRIL and 24-hour urinary protein in the four groups were compared.The application value of the combined detection in idiopathic membranous nephropathy was evaluated.Results:The levels of anti PLA2R antibody,APRIL and 24-hour urinary protein in patients with idiopathic membranous nephropathy were significantly higher than those in the control group(all P<0.05).There was no significant difference in the levels of serum anti PLA2R antibody,APRIL and 24-hour urinary protein among observation group 1,2 and 3(all P>0.05).The above indexes in the observation group 3 were higher than those in the observation group 1 and 2,and the above indexes in the observation group 2 were higher than those in the observation group 1(all P<0.05).The higher the expression of anti PLA2R antibody in serum,the higher the levels of APRIL and 24-hour urinary protein in patients,and there was a significant positive correlation between them(all P<0.05).Conclusion:The combined detection of serum anti PLA2R antibody,APRIL and 24-hour urinary protein in idiopathic membranous nephropathy can not only dete

关 键 词：特发性膜性肾病 血清抗PLA2R抗体 增殖诱导配体 24 h尿蛋白水平 应用价值 

分 类 号：R692[医药卫生—泌尿科学]