单核苷酸多态性在近交系小鼠遗传检测方面的研究进展  

Research Progress of Single Nucleotide Polymorphismin Genetic Monitoring of Inbred Laboratory Mice

作　　者：尚艳姣 周小军 袁征 邱业峰 SHANG Yanjiao;ZHOU Xiaojun;YUAN Zheng;QIU Yefeng(Laboratory Animal Center,Academy of Military Medical Science,Academy of Military Science,Beijing 100071,China)

机构地区：[1]军事科学院军事医学研究院实验动物中心,北京100071

出　　处：《实验动物科学》2022年第4期69-73,共5页Laboratory Animal Science

摘　　要：随着分子生物学技术的迅速发展,单核苷酸多态性(SNP)检测技术也得以不断的完善和发展。SNP作为第三代遗传标记,已经成为小鼠遗传检测的重要手段。SNP检测是在DNA水平进行的检测,依赖于完整的基因组信息注释。本文概述了小鼠基因组学的发展,以及SNP在近交系小鼠遗传检测方面的研究进展。With the rapidly advancesin molecular biology technology,single nucleotide polymorphisms(SNP)detection technology has been constantly developed.As the third generation of genetic marker,SNP detection has become an important means of genetic monitoring in mice.SNP detection is carried out at the DNA level,thus its accuracy depends on annotation of mice genome.In this paper,the progress of genomics and SNP in genetic monitoring of inbred mice were summarized.

关 键 词：小鼠 基因组 SNP 遗传检测 

分 类 号：Q95-3[生物学—动物学]