猴痘病毒的研究及治疗进展  

Research and treatment progress of monkeypox virus

作　　者：颜琳洁 钟武 YAN Lin-jie;ZHONG Wu(National Engineering and Technology Center of Emergency Prevention and Control Drugs,Institute of Pharmacology&Toxicology of the Academy of Military Medical Sciences,Beijing 100850,China)

机构地区：[1]军事科学院军事医学研究院毒物药物研究所国家应急防控药物工程技术研究中心,北京100850

出　　处：《临床药物治疗杂志》2022年第11期1-7,共7页Clinical Medication Journal

基　　金：国家重大新药创制科技重大专项(2018ZX09711003)。

摘　　要：猴痘病毒是一种人畜共患病病毒,可导致一种类似天花的疾病。目前针对猴痘病毒的最佳感染控制和治疗策略尚未建立,猴痘病毒感染引起的皮肤病变消退后上呼吸道病毒DNA长时间脱落,对现行感染防控指导提出挑战。本文对当前世界范围猴痘疫情的现状、流行病学和猴痘病毒感染的细胞和动物模型以及治疗猴痘的具有临床前景的抗病毒药物进行综述。Monkeypox virus is a zoonotic virus that causes a disease similar to smallpox.Currently,optimal infection con⁃trol and treatment strategies for monkeypox virus have not been established.Monkeypox virus infection causes prolonged DNA shedding of upper respiratory tract after skin lesions subside,which challenges current infection prevention and control guide⁃lines.This review discusses the current worldwide outbreak and epidemiology of monkeypox,the cell and animal models for monkeypox virus infection,as well as the promising antiviral drugs for the treatment of monkeypox.

关 键 词：猴痘病毒 抗病毒药物 替韦立马 布林西多福韦 

分 类 号：R978.7[医药卫生—药品]